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FLASH GENE
Symbol TPRX1 contributors: mct - updated : 10-04-2020
HGNC name tetra-peptide repeat homeobox 1
HGNC id 32174
Location 19q13.33      Physical location : 48.304.499 - 48.306.861
Synonym name
  • CRX like homeobox 2
  • Synonym symbol(s) TPRX, FLJ40321
    DNA
    TYPE functioning gene
    STRUCTURE 2.36 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1839 - 411 - 2009 19274049
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivemale systemtestis    Homo sapiens
    Visualeye   lowly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an homeodomain
  • 58 repeated copies of the motif Pro-Ile-Pro-Gly
  • HOMOLOGY
    interspecies ortholog to murine Crxos
    Homologene
    FAMILY
  • TPRX homeobox gene family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    intracellular,nucleus,nucleolus
    text
  • expression level for all five genes (ARGFX, DPRX, LEUTX, TPRX1) crashes after the morula stage, and the genes are not strongly expressed again in embryonic, foetal or adult tissues
  • clearly localised to the nucleus, apart from nucleoli
  • basic FUNCTION
  • playing a role in the regulation of transcription, DNA-dependent
  • LEUTX may have originated by tandem duplication from the CRX gene in the Otx gene family, or from the mammalian TPRX1 gene which itself may have originated from CRX
  • ARGFX, TPRX1 LEUTX, DPRX genes arose by asymmetric evolution from the CRX homeobox gene at the base of eutherian evolution, as part of a dynamic series of duplications
  • ARGFX, LEUTX and TPRX1 regulate a set of developmentally-important genes precisely modulated at the time when the earliest cell fate decisions are made
  • ETCHbox (Eutherian Totipotent Cell Homeobox) gene
  • partial overlap of function between LEUTX and TPRX1
  • PRD-like homeodomain protein implicated in the regulation of human embryo genome activation and preimplantation embryo development
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • LEUTX and TPRX1 genes act on a similar set of genes and genetic pathways between the 4-cell stage and the blastocyst, in an antagonistic manner to the effects of ARGFX
  • cell & other
    REGULATION
    Other activated with embryonic genome activation at the 8-cell stage
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS