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FLASH GENE
Symbol TPPP3 contributors: mct - updated : 30-06-2017
HGNC name tubulin polymerization-promoting protein family member 3
HGNC id 24162
Location 16q22.1      Physical location : 67.423.713 - 67.427.421
Synonym name brain specific protein
Synonym symbol(s) CGI-38, p25gamma, p20
DNA
TYPE functioning gene
STRUCTURE 3.73 kb     5 Exon(s)
MAPPING cloned Y linked N status confirmed
Map cen - D16S3086 - D16S421 - TPPP3 - D16S3107 - D16S3085 - qter
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 splicing 1068 18.9 176 - 2006 17105200
5 splicing 1159 18.9 176 - 2006 17105200
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus   moderately
Nervousbrain   specificHomo sapiens
Reproductivefemale systemplacenta  moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivecartilage    Homo sapiens
Connectivedensetendon   Homo sapiens
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus Tppp3 (96 pc)
homolog to murine Tppp3 (96.6 pc)
intraspecies paralog to TPPP, TPPP2
Homologene
FAMILY
  • Tubulin polymerization-promoting protein family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • associated with a basic function of cilia
  • intrinsically unstructured protein that induces tubulin polymerization
  • TPPP and TPPP3 are intrinsically unstructured proteins (IUPs) that bind and polymerize tubulin and stabilize microtubules, but TPPP2 does not
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
  • specifically binds to MTs and positively regulates MTs assembly, which leads to significant ultrastructural alterations of the MTs network
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • onset of TPPP3 expression in joints coincides with cavitation, representing a molecular marker that can be used to indicate this stage in joint transition in joint differentiation
  • Therapy target
    ANIMAL & CELL MODELS