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FLASH GENE
Symbol TPM4 contributors: mct/npt - updated : 04-05-2009
HGNC name tropomyosin 4
HGNC id 12013
Location 19p13.12      Physical location : 16.178.316 - 16.213.813
Synonym name TPM4-ALK fusion oncoprotein type 2
Synonym symbol(s) TM30p1
DNA
TYPE functioning gene
STRUCTURE 26.08 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
NAKAP95 19p13.12-p13.11 hypothetical protein MGC3169 WIZ 19p13.1 widely-interspaced zinc finger motifs FLJ21438 19p13.12 hypothetical protein FLJ21438 PGRP-L 19p13.12 peptidoglycan recognition protein L precursor FLJ39501 19p13.12 hypothetical protein FLJ39501 LOC390896 19 similar to Cytochrome P450 4F6 (CYPIVF6) LOC388513 19 similar to 60S ribosomal protein L23a CYP4F8 19p13.1 cytochrome P450, family 4, subfamily F, polypeptide 8 CYP4F3 19p13.1 cytochrome P450, family 4, subfamily F, polypeptide 3 CYP4F12 19p13.1 cytochrome P450, family 4, subfamily F, polypeptide 12 OR10H2 19p13.1 olfactory receptor, family 10, subfamily H, member 2 OR10H3 19p13.1 olfactory receptor, family 10, subfamily H, member 3 LOC388514 19 similar to Cytochrome P450 4F12 (CYPIVF12) LOC284433 19p13.12 hypothetical gene supported by NM_013940 OR10H1 19p13.1 olfactory receptor, family 10, subfamily H, member 1 LOC388515 19 LOC388515 LOC339377 19p13.12 similar to 4930572L20Rik protein CYP4F2 19p13.1-p12 cytochrome P450, family 4, subfamily F, polypeptide 2 CYP4F11 19p13.1 cytochrome P450, family 4, subfamily F, polypeptide 11 LOC126541 19p13.12 similar to Olfactory receptor 10H4 LOC126537 19p13.12 similar to cytochrome P-450 FLJ25328 19p13.12 hypothetical protein FLJ25328 TPM4 19p13.1 tropomyosin 4 MEL 19p13.1 mel transforming oncogene (derived from cell line NK14)- RAB8 homolog HSH2 19p13.12 mel transforming oncogene (derived from cell line NK14)- RAB8 homolog KIP3 DKFZP586O0120 AP1M1 19p13.2 adaptor-related protein complex 1, mu 1 subunit KLF2 19p13.13-p13.11 Kruppel-like factor 2 (lung) EPS15R 19p13.12 Kruppel-like factor 2 (lung) CALR3 19p13.11 calreticulin 3 FLJ21742 19p13.12 hypothetical protein FLJ21742 CHERP 19p13.1 calcium homeostasis endoplasmic reticulum protein SLC35E1 19p13.12 solute carrier family 35, member E1 CRSP7 19p13.12 cofactor required for Sp1 transcriptional activation, subunit 7, 70kDa MGC2747 19p13.12 hypothetical protein MGC2747 MGC3169 19p13.12 hypothetical protein MGC3169
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 2630 32.6 284 - Lin (2008)
8 - 2645 28.4 248 - Lin (2008)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 pharynx   highly
Reproductivefemale systemuterus  highly
Skin/Tegumentskin   moderately
Urinarybladder   highly
 kidney    
Visualeyeanterior segmentcornea  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer dimer
HOMOLOGY
Homologene
FAMILY
  • tropomyosin family
  • CATEGORY motor/contractile , structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microfilament
    basic FUNCTION
  • playing a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction
  • TPM4-defined cytoskeleton is a marker of growth and repair/regeneration in response to injury, disease state and stress in skeletal muscle (Vlahovich 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • dimerizing to form a helical coiled coil constituent binding to actin in the troponin complex (thin filamant) that regulates calcium-dependent binding of actin and myosin and muscle contraction
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    to ALK in anaplastic large cell lymphoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS