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FLASH GENE
Symbol TPM3 contributors: mct/npt - updated : 30-05-2018
HGNC name tropomyosin 3
HGNC id 12012
Corresponding disease
CFTD3 congenital fibre type disproportion 3
NEM1 nemaline myopathy 1
Location 1q21.3      Physical location : 154.127.779 - 154.164.609
Synonym name
  • non muscle tropomyosin 5
  • tropomyosin gamma
  • cytoskeletal tropomyosin TM30
  • heat-stable cytoskeletal protein 30 kDa
  • tropomyosin alpha-3 chain
  • epididymis luminal protein 189
  • epididymis secretory sperm binding protein Li 82p
  • Synonym symbol(s) TRK, TC22, MGC14582, MGC3261, MGC72094, FLJ41118, TM-5, TM3, TM30, TM30nm, hscp30, Tm5NM-1
    DNA
    TYPE functioning gene
    STRUCTURE 36.83 kb     10 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    text structure one alternative non muscle form lacking 2 exon
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing - - - colon cancer cells and polyps with mild and severe dyasplasia 2015 25369766
    8 - 4539 28.8 247 - 2015 25369766
    8 - 3212 28.9 248 - 2015 25369766
    7 - 3149 - 227 - 2015 25369766
    9 - 3291 - 248 - 2015 25369766
    10 - 7109 32.8 285 - 2015 25369766
    7 - 3078 - 182 - 2015 25369766
    8 - 3212 - 248 - 2015 25369766
    8 - 4539 - 247 - 2015 25369766
    9 - 3291 - 248 - 2015 25369766
    8 - 3058 - 158 - 2015 25369766
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemprostate  highly
    Respiratoryrespiratory tractlarynx  highly
    Visualeyeanterior segmentcornea  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer dimer
    HOMOLOGY
    Homologene
    FAMILY
  • tropomyosin family
  • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microfilament
    basic FUNCTION
  • playing a central role in association with the troponin complex, in the calcium dependent regulation of vertebrate striated
  • having functions in regulating cell motility and in modulating the anti-angiogenic activity of cleaved high molecular weight kininogen (HKa)(Jin 2008)
  • promotes the formation of filopodia by regulating the recruitment of actin-binding proteins to actin filaments
  • its expression has an important role in temporal regulation of cell migration during wound healing
  • plays crucial roles in maintaining cortical actin integrity and asymmetric cell division during oocyte maturation, and dynamic regulation of cortical actin by TPM3 is critical to ensure proper polar body protrusion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text slow type I muscle fibers
    PATHWAY
    metabolism
    signaling
    a component
  • dimerizing to form a helical coiled coil constituent binding to actin in the troponin complex (thin filamant) that regulates calcium-dependent binding of actin and myosin and muscle contraction
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ACTA1 and TNNT1 and ultimatily regulating the development of muscle contraction
  • TTC9 interacts specifically with actin-binding protein tropomyosin TPM3 which stabilizes actin filament and focal adhesion
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NEM1 , CFTD3
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    fusion with NTRK1 in papillary thyroid carcinoma, with ALK in anaplastic large cell lymphoma
    tumoral fusion      
    with PDGFRB in chronic eosinophilic leukemia (Rosati 2006)
    tumoral     --over  
    may be important in esophageal squamous cell carcinoma (ESCC) invasion and metastasis (pMID: 28138712)
    constitutional   deletion    
    cause a hypercontractile congenital muscle stiffness phenotype
    tumoral fusion      
    TPM3-ALK fusion gene, is the main causes of Inflammatory myofibroblastic tumor (IMT)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • serum anti-TPM3, anti-TMOD3, anti-STOML2 could be new markers for the early diagnosis of endometriosis
  • Therapy target
    SystemTypeDisorderPubmed
    neuromuscularmyopathycongenital
    administration of troponin activators may constitute a promising therapeutic approach to minimize generalized skeletal muscle weakness in Nemaline myopathy
    ANIMAL & CELL MODELS
    Tm slow (Met 9Arg) mice