SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endosome
|
| intracellular,cytoplasm,organelle,lysosome
|
text
| specifically targeted to lysosomal membranes |
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localizes to the melanosome-limiting membrane |
basic FUNCTION
| displays the basic properties of native NAADP-dependent Ca(2+)-release channels |
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is a regulator of pigmentation |
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major component of the long-sought lysosomal NAADP-dependent Ca(2+)-release channel |
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lysosomal Ca2+ release channel targeted by NAADP |
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a highly selective Ca2+ channel |
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exhibits many unique functional characteristics that can explain the idiosyncrasies of cellular NAADP signaling characteristics |
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functional ion channel activated by NAADP (Nicotinic acid adenine dinucleotide phosphate) |
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behaves as a functional ion channel and, crucially, possesses the conduction properties required of an intracellular Ca2+ release channel, and operating as a dual sensor of luminal pH and Ca2+ |
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is a novel critical molecule for osteoclastogenesis |
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is a highly Na+-selective channel in the endolysosome |
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TPCN1, TPCN2, do not contribute directly to NAADP-induced endolysosomal Ca2+ release |
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TPCN1 and TPCN2 have important but distinct roles in the endo-lysosomal pathway |
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TPCN2 impacts mammalian target of rapamycin reactivation during the process of autophagy and contributes to maintenance of muscle homeostasis |
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endolysosomal channels TPCN1 and TPCN2 are essential for appropriate basal and induced autophagic flux in cardiomyocytes, and also that they are differentially expressed in male and female hearts |
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is not absolutely required for normal glucose- or incretin-stimulated insulin secretion from the beta-cell |
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significantly different gating and ion conducting properties of TPCN1 and TPCN2 suggest that these two ion channels may play complementary physiological roles as Ca(2+) -release channels of the endolysosomal system |
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regulates pigmentation through two fundamental determinants of melanosome function: pH and size |