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FLASH GENE
Symbol TPBG contributors: - updated : 31-05-2006
HGNC name trophoblast glycoprotein
HGNC id 12004
Location 6q14-q15      Physical location : 83.072.922 - 83.077.131
Synonym name antigen identified by monoclonal antibody 5T4 (glycoprotein MW 72kD)
Synonym symbol(s) M6P1,5T4,5T4-AG
DNA
TYPE functioning gene
STRUCTURE 3.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site   transcription factor
text structure a number of potential SP1-binding sites
MAPPING cloned Y linked N status provisional
Physical map
C6orf152 6q14.3 chromosome 6 open reading frame 152 SH3BGRL2 6q13-15 SH3 domain binding glutamic acid-rich protein like 2 ELOVL4 6q14 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4 LOC391944 6 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) TTK 6q12-q21 TTK protein kinase LOC285786 6q14.3 similar to KIAA1424 protein LOC389412 6 similar to Rho GTPase activating protein 21; Rho-GTPase activating protein 10 BCKDHB 6p22-p21 branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease) LOC391945 6 similar to 60S ribosomal protein L17 (L23) LOC340171 6q14.3 hypothetical LOC340171 LOC153956 6q14.3 similar to citrate (si)-synthase (EC 4.1.3.7) precursor - pig C6orf37 6q14 chromosome 6 open reading frame 37 LOC389413 6 LOC389413 IBTK 6q14.3 inhibitor of Bruton agammaglobulinemia tyrosine kinase TPBG 6q14-q15 trophoblast glycoprotein C6orf157 6q15 chromosome 6 open reading frame 157 KIAA1117 6q15 chromosome 6 open reading frame 157 PGM3 6q14.1-q15 phosphoglucomutase 3 RWDD2 6q15 RWD domain containing 2 ME1 6q12 malic enzyme 1, NADP(+)-dependent, cytosolic C6orf158 6q15 chromosome 6 open reading frame 158 SNAP91 6q13 synaptosomal-associated protein, 91kDa homolog (mouse) C6orf159 6q15 chromosome 6 open reading frame 159 NCB5OR 6pter-q22.33 NADPH cytochrome B5 oxidoreductase C6orf117 6q14.3 chromosome 6 open reading frame 117 C6orf84 6pter-q16.1 chromosome 6 open reading frame 84 LOC346033 6q15 similar to SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e1 TBX18 6p14-q15 T-box 18 LOC391946 6 similar to ribosomal protein L31
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrinepancreas   highly
Nervousbrain    
Reproductivemale systemprostate  highly
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal putative signal sequence,a 310-residue extracellular region,a membrane anchorage domain and a 44-amino acid cytoplasmic tail with a potential phosphorylation site
  • seven potential N-glycosylation sites and seven leucine-rich repeats which are located in two regions separated by a hydrophilic stretch in the extracellular region
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Tpbg
    Homologene
    FAMILY
    CATEGORY adhesion , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION playing a role in placentation or metastasis
    CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS