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FLASH GENE
Symbol TPBG contributors: - updated : 31-05-2006
HGNC name trophoblast glycoprotein
HGNC id 12004
Location 6q14-q15      Physical location : 83.072.922 - 83.077.131
Synonym name antigen identified by monoclonal antibody 5T4 (glycoprotein MW 72kD)
Synonym symbol(s) M6P1,5T4,5T4-AG
DNA
TYPE functioning gene
STRUCTURE 3.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site   transcription factor
text structure a number of potential SP1-binding sites
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrinepancreas   highly
Nervousbrain    
Reproductivemale systemprostate  highly
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal putative signal sequence,a 310-residue extracellular region,a membrane anchorage domain and a 44-amino acid cytoplasmic tail with a potential phosphorylation site
  • seven potential N-glycosylation sites and seven leucine-rich repeats which are located in two regions separated by a hydrophilic stretch in the extracellular region
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Tpbg
    Homologene
    FAMILY
    CATEGORY adhesion , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION playing a role in placentation or metastasis
    CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS