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FLASH GENE
Symbol TP53RK contributors: mct - updated : 25-09-2019
HGNC name TP53 regulating kinase
HGNC id 16197
Corresponding disease
GAMOS4 Galloway-Mowat syndrome 4
Location 20q13.12      Physical location : 45.313.004 - 45.318.276
Synonym name
  • p53-related protein kinase
  • chromosome 20 open reading frame 64
  • EKC/KEOPS complex subunit TP53RK
  • Synonym symbol(s) PRPK, dJ101A2.2, C20orf64, Nori-2, BUD32, GAMOS4, Nori-2p, dJ101A2
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 5.08 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 3180 28 253 - 2003 12659830
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text eye
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a tyrosine kinase, catalytic domain
  • HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • Tyr protein kinase family
  • BUD32 subfamily
  • CATEGORY receptor membrane serine/threonine kinase
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • playing a role in the cell-cycle and cell apoptosis throught phosphorylation of TP53
  • kinase that restrains apoptosis after mitotic stress
  • CELLULAR PROCESS cell cycle
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CGI-121
  • RAB35 modulate TP53 transcriptional activity ofTP53RK
  • TP53RK signaling pathway promotes colon cancer metastasis by modulating BIRC5 stability
  • cell & other
    REGULATION
    Phosphorylated by activation of TP53RK is mediated by another kinase, AKT1 which phosphorylates TP53RK at Ser250
    ASSOCIATED DISORDERS
    corresponding disease(s) GAMOS4
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • in cancers, TP53RK levels could provide a molecular marker to predict response to antimitotic agents
  • could be a new prognostic marker for the survival of colon cancer patients
  • Therapy target
    ANIMAL & CELL MODELS