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FLASH GENE
Symbol TP53INP2 contributors: mct/npt - updated : 07-05-2010
HGNC name tumor protein p53 inducible nuclear protein 2
HGNC id 16104
Location 20q11.22      Physical location : 33.292.147 - 33.301.237
Synonym name
  • chromosome 20 open reading frame 110
  • p53-inducible protein U
  • tumor protein p53 inducible nuclear protein 2
  • diabetes and obesity regulated
  • Synonym symbol(s) FLJ21759, FLJ23500, dJ1181N3.1, PINH, C20orf110, DKFZp434B2411, DKFZp434O0827, PIG-U, DOR
    DNA
    TYPE functioning gene
    STRUCTURE 9.10 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 4124 24 220 - Nowak (2009)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Skeletonaxialskullfacemaxilla 
    Visualeyeuveachoroid  
     eyeretina   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY storage
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text translocates from the nucleus to autophagosomes after activation of autophagy (Nowak 2009)
    basic FUNCTION
  • alternative splicing of an exon in its 5 prime untranslated region is a key event downstream of HNRNPA2B1 that is necessary for cells to invade the extracellular matrix (Moran-Jones 2009)
  • scaffold protein that recruits MAP1LC3A and/or LC3-related proteins to the autophagosome membrane by interacting with the transmembrane protein TMEM49 and is a novel gene involved in the autophagy of mammalian cells (Nowak 2009)
  • involved in the autophagy of mammalian cells (Nowak 2009)
  • scaffold protein that recruits Atg8-like proteins to the autophagosome membrane by interacting with the transmembrane protein TMEM49 (Nowak 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to the Atg8-like proteins, as well as with the autophagosome transmembrane protein TMEM49 (Nowak 2009)
  • cell & other
    REGULATION
    Other HNRNPA2B1 regulates alternative mRNA splicing of TP53INP2 to control invasive cell migration (Moran-Jones 2009)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS