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FLASH GENE
Symbol TP53INP1 contributors: mct - updated : 14-05-2012
HGNC name tumor protein p53 inducible nuclear protein 1
HGNC id 18022
Location 8q22.1      Physical location : 95.938.200 - 95.961.615
Synonym symbol(s) SIP, FLJ22139, P53DINP1, Teap, TP53DINP1, TP53INP1A, TP53INP1B
DNA
TYPE functioning gene
STRUCTURE 23.42 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
MRPS16P1 8q21.3 hypothetical protein FLJ39553 CBFA2T1 8q22 core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related LOC389675 8 similar to 40S ribosomal protein S26 LOC389676 8 LOC389676 LOC392251 8 similar to KIAA1588 protein LOC137392 8q22.1 similar to CG6405 gene product LOC389677 8 similar to RIKEN cDNA 3000004N20 PRO1905 8q22.1 hypothetical protein PRO1905 MGC26979 8q22.1 hypothetical protein MGC26979 LOC157667 8q22.1 similar to myosin regulatory light chain-like PPM2C 8q22.1 protein phosphatase 2C, magnesium-dependent, catalytic subunit CDH17 8q22.1 cadherin 17, LI cadherin (liver-intestine) GEM 8q22.3 GTP binding protein overexpressed in skeletal muscle LOC392252 8 similar to ribosomal protein S4, X-linked RAD54B 8q21.3-q22 similar to ribosomal protein S4, X-linked FSBP 8q22.1 fibrinogen silencer binding protein DKFZP434I116 8q22.1 DKFZP434I116 protein FLJ20171 8q22.1 hypothetical protein FLJ20171 LOC286148 8q22.1 hypothetical protein LOC286148 FLJ20530 8q22.1 hypothetical protein FLJ20530 CCNE2 8q22.1 cyclin E2 LOC392253 8 similar to Ac2-210 TP53INP1 8q22 tumor protein p53 inducible nuclear protein 1 MGC40214 8q22.1 hypothetical protein MGC40214 PLEKHF2 8q22.1 pleckstrin homology domain containing, family F (with FYVE domain) member 2 LOC157657 8q22.1 hypothetical protein LOC157657 LOC392254 8 similar to glyceraldehyde-3-phosphate dehydrogenase LOC392255 8 similar to growth and differentiation factor 6 UQCRB 8q22 ubiquinol-cytochrome c reductase binding protein CGI-12 8q22.1 CGI-12 protein PTDSS1 8q22 phosphatidylserine synthase 1 SDC2 8q22-q23 syndecan 2 (heparan sulfate proteoglycan 1, cell surface-associated, fibroglycan) PGCP 8q22.2 plasma glutamate carboxypeptidase KIAA1750 8q22.1 KIAA1750 protein LOC286150 8q22.1 similar to 40S ribosomal protein S2 LYRIC 8q22.1 LYRIC/3D3 LAPTM4B 8q22.1 lysosomal associated protein transmembrane 4 beta LOC389678 8 similar to hypothetical protein LOC51249 RPS23P1 8q23 ribosomal protein S23 pseudogene 1 MATN2 8q22 matrilin 2 RPL30 8q22-q24 ribosomal protein L30 FLJ39553 8q22.2 hypothetical protein FLJ39553
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 5587 - 164 - 2005 16044147
TP53INP1 beta or SIP18
4 - 5628 27.2 240 - 2005 16044147
TP53INP1 alpha or SIP27
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   moderately
Digestiveliver   highly
 mouthtongue  moderately
Hearing/Equilibriumear   highly
Lymphoid/Immunelymph node   highly
 thymus   predominantly
Nervousnerve   highly
Reproductivemale systemtestis  moderately
Respiratoryrespiratory tracttrachea  moderately
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus Trp53inp1 (86.2 pc)
homolog to murine Trp53inp1 (87.9 pc)
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,nucleoplasm,nuclear bodies,PML
text
  • mainly nuclear, but relocalizes in autophagosomes during autophagy where it is eventually degraded
  • basic FUNCTION
  • promoting p53/TP53 phosphorylation on Ser-46 and subsequent apoptosis, in response to double-strand DNA breaks
  • associated with TP73 to regulate cell cycle progression and apoptosis, independently from TP53
  • regulating TP53 transcriptional activity
  • stress-induced protein that plays a role in both cell cycle arrest and TP53-mediated apoptosis
  • having a novel activity on the regulation of SPARC expression that could explain in part its tumor suppressor function in pancreatic adenocarcinoma by modulating cellular spreading during the metastatic process
  • could act as a tumor suppressor by inducing cell death by caspase-dependent autophagy
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with HIPK2
  • interacting with the p53
  • MYC bound to the core promoter of TP53INP1 and recruited DNA methyltransferase 3A to methylate the local promoter region, leading to the inhibition of TP53INP1 expression
  • interacts physically with TP53 and is a major player in the TP53-driven oxidative stress response
  • able to interact with ATG8-family proteins and to induce autophagy-dependent cell death
  • cell & other
    REGULATION
    induced by adriamycin, gamma irradiation and H(2)O(2), in a p53-dependent way
    ultraviolet irradiation, at lower levels
    Other upregulated by ZBTB16
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in pancreatic cancer (
    tumoral     --over  
    is a worse prognostic factor in prostate carcinoma, particularly predictive of biological cancer relapse
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    could be considered as a relevant-specific target for molecular therapy of castration-resistant prostate cancer
    ANIMAL & CELL MODELS