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FLASH GENE
Symbol TP53I3 contributors: mct - updated : 10-10-2012
HGNC name tumor protein p53 inducible protein 3
HGNC id 19373
Location 2p24.1      Physical location : 24.300.304 - 24.307.728
Genatlas name P53-induced gene 3
Synonym name quinone oxidoreductase homolog
Synonym symbol(s) PIG3
DNA
TYPE functioning gene
STRUCTURE 7.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
motif repetitive sequence
text structure motif (TGYCC)15 microsatellite in the promoter is the first tp53 responsive element shown to be polymorphic
MAPPING cloned Y linked N status provisional
Physical map
LOC388930 2 LOC388930 FLJ14126 2p24.1 hypothetical protein FLJ14126 KBTBD9 2p24.1 kelch repeat and BTB (POZ) domain containing 9 KIAA1240 2p24.1 KIAA1240 protein LOC165324 LOC388931 2 hypothetical gene supported by BX647146 FLJ21945 2p24.1 hypothetical protein FLJ21945 FKBP1B 2p24.1 FK506 binding protein 1B, 12.6 kDa P14 2pter-p25.1 pre-mRNA branch site protein p14 TP53I3 2p24.1-p23.3 tumor protein p53 inducible protein 3 LOC375189 2p24.1 hypothetical protein LOC375189 LOC388932 2 similar to FLJ30851 protein LOC388933 2 LOC388933 ITSN2 2pter-p25.1 intersectin 2 PRO2015 2p24.1 hypothetical protein PRO2015 NCOA1 2p23 nuclear receptor coactivator 1 LOC391356 2 similar to ENSANGP00000018456 MGC11266 2p24.1 hypothetical protein MGC11266 ADCY3 2p23 adenylate cyclase 3 LOC51277 LOC388934 2 LOC388934 LOC388935 2 LOC388935 KIAA0953 2p24.1 LOC388935 POMC 2p23.3 proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin) DNMT3A 2p23 DNA (cytosine-5-)-methyltransferase 3 alpha
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 2042 - 332 - 2002 11919562
6 - 1643 - 332 - 2002 11919562
4 - 961 - 248 - 2002 11919562
- splicing - - - - 2008 18801469
  • modulated in response to UV radiation
  • numerous factors contribute to the normal alternative splicing of PIG3ex4 and UV-inducible increases in this process require that the splicing of this exon be maintained in a sufficiently weakened state under normal conditions
  • EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbrainmedulla oblongata  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebonesubchondral  
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text eye
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    zinc binding dehydrogenase domain
    HOMOLOGY
    intraspecies homolog to quinone oxidoreductase
    Homologene
    FAMILY medium chain dehydrogenase/reductase superfamily
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • involved in TP53-mediated cell death
  • its action is through oxidative stress produced by its enzymatic activity and provides essential knowledge for eventual control of apoptosis
  • role in the activation of DNA damage checkpoints, after UV irradiation or radiomimetic drug neocarzinostatin (NCS)
  • critical component of the DNA damage response pathway, having a direct role in the transmission of the DNA damage signal from damaged DNA to the intra-S and G2/M checkpoint machinery in human cells
  • may possibly have a role in cancer cell survival
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • a novel signaling pathway of GPX3-TP53I3 in the regulation of cell death in prostate cancer
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • contributes to the recruitment of TP53BP1, MRE11A, RAD50 and NBS1 to the sites of DNA break lesions in response to DNA damage
  • cell & other
    REGULATION
    induced by Tp53
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to cancer
    Variant & Polymorphism repeat microsatellite affecting an individual susceptibility to cancer
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS