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FLASH GENE

Symbol

TOX2

contributors: mct - updated : 27-03-2017

HGNC name	TOX high mobility group box family member 2
HGNC id	16095

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	20q13.12      Physical location : 42.543.491 - 42.698.252
Genatlas name	Thymocyte selection-associated high mobility group box protein family member 2
Synonym name	chromosome 20 open reading frame 100
	granulosa cell HMG box protein 1
Synonym symbol(s)	MGC15880, DJ495O3.1, DJ1108D11.2, C20orf100, GCX-1, GCX1

DNA

TYPE	functioning gene
STRUCTURE	154.76 kb     10 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001098797 9 - 2505 NP_001092267 - 506 - 2004 14764631 NM_001098796 9 - 2433 NP_001092266 - 464 - 2004 14764631 NM_032883 10 - 2558 NP_116272 - 464 - 2004 14764631 NM_001098798 8 - 2428 NP_001092268 51.6 488 - 2004 14764631

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune natural killer Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

highly conserved high mobility group DNA-binding domain shared with the other TOX members

HOMOLOGY

Homologene

FAMILY

TOX family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm

basic FUNCTION	may be playing an important role in the hypothalamo-pituitary-gonadal system
	participating in other specific events related to reproduction, particularly in the female
	given the essential function of TBX21 in NK cell differentiation, TOX2 therefore plays a crucial role in controlling normal NK cell development by acting upstream of TBX21

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

TOX2 was independent of ETS1 but could directly upregulate the transcription of TBX21 (encoding T-BET)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS