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FLASH GENE
Symbol TOX contributors: SGE/npt/pgu - updated : 27-03-2017
HGNC name thymocyte selection-associated high mobility group box
HGNC id 18988
Location 8q12.1      Physical location : 59.717.976 - 60.031.767
Synonym name thymus high mobility group box protein Tox
Synonym symbol(s) KIAA0808, TOX1
DNA
TYPE functioning gene
SPECIAL FEATURE opposite orientation
text opposite orientation with DEL8q12
STRUCTURE 313.79 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 4131 - 526 - 2002 11850626
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   lowly
Nervousbrain   highly
 spinal cord    
Reproductivefemale systemovary  highly
 male systemtestis  highly
Urinarykidney   lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one HMG box DNA binding domain
  • core motif of 35 invariant and conserved amino acids
  • a central conserved bipartite nuclear localization signal (NLS)
  • HOMOLOGY
    interspecies homolog to murine Tox (94.1pc)
    homolog to rattus Tox (94.7pc)
    intraspecies homolog to KIAA0737
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • may function to regulate T-cell development
  • necessary for the development of all CD4 T lineages , TOX-dependent transition to the CD4+-CD8lo stage is required for continued development of class II major histocompatibility complex-specific T-cells
  • is sufficient to induce changes in coreceptor gene expression associated with beta-selection, including CD8-gene methylation
  • also sufficient to initiate positive selection to the CD8 lineage in the absence of MHC-TCR interactions
  • nuclear factor thymocyte selection-associated high-mobility group box, which is known for its role in the generation of the immune system, including the development of T cells and natural killer cells, and lymph node organogenesis (
  • appears to play an important role in prompting the critical transition from infection to active pulmonary disease, in tuberculosis
  • is likely an essential regulator of T-cell and natural killer (NK) cell differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to pulmonary tuberculosis (PTB)
    Variant & Polymorphism SNP
  • around rs1568952 and rs2726600 a cluster of SNPs strongly associated with early-onset PTB
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS