basic FUNCTION
| may function to regulate T-cell development |
|
necessary for the development of all CD4 T lineages , TOX-dependent transition to the CD4+-CD8lo stage is required for continued development of class II major histocompatibility complex-specific T-cells |
|
is sufficient to induce changes in coreceptor gene expression associated with beta-selection, including CD8-gene methylation |
|
also sufficient to initiate positive selection to the CD8 lineage in the absence of MHC-TCR interactions |
|
nuclear factor thymocyte selection-associated high-mobility group box, which is known for its role in the generation of the immune system, including the development of T cells and natural killer cells, and lymph node organogenesis ( |
|
appears to play an important role in prompting the critical transition from infection to active pulmonary disease, in tuberculosis |
|
is likely an essential regulator of T-cell and natural killer (NK) cell differentiation |
|
|