protein
| impaired interaction of torsinA with TOR1AIP2 and/or TOR1AIP1 may thus contribute to the development of dystonia |
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depending on redox status, an ATP hydrolysis mutant of torsinA interacts with lamina-associated polypeptide 1 (TOR1AIP1) and lumenal domain like LAP1 (TOR1AIP2) |
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binds to lamins and chromatin, probably contributing to the maintenance of the nuclear envelope architecture |
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activity of TorsinA and the related ATPase TorsinB strictly depends on TOR1AIP1 and TOR1AIP2, that are integral parts of the Torsin/cofactor AAA ring, forming a composite, membrane-spanning assembly |
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TOR1AIP1 and TOR1AIP2, reversibly co-assemble with and activate torsin A |