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FLASH GENE
Symbol TOP3B contributors: - updated : 16-05-2007
HGNC name topoisomerase (DNA) III beta
HGNC id 11993
Location 22q11.22      Physical location : 22.311.403 - 22.337.147
Synonym symbol(s) FLJ39376
EC.number 5.99.1.2
DNA
TYPE functioning gene
STRUCTURE 25.00 kb     18 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
cytosine-phosphate-guanine/HTF
Binding site
text structure
  • multiple transcription initiation sites
  • lacks a canonical TATA box or initiation element and is moderately high in GC content
  • a 5'GGAACC3' element between -117 and -112 plays a critical role in the up-regulation of the basal transcription activity
  • MAPPING cloned Y linked   status provisional
    Physical map
    PPM1F 22q11.22 protein phosphatase 1F (PP2C domain containing) FLJ23185 22q11.22 hypothetical protein FLJ23185 TOP3B 22q11 topoisomerase (DNA) III beta LOC391306 22 similar to Hypothetical protein DJ1198H6.2 IGLVI-70 22q11.2 immunoglobulin lambda variable (I)-70 IGLV4-69 22q11.2 immunoglobulin lambda variable 4-69 IGLVI-68 22q11.2 immunoglobulin lambda variable (I)-68 IGLV10-67 22q11.2 immunoglobulin lambda variable 10-67 IGLVIV-66-1 22q11.2 immunoglobulin lambda variable (IV)-66-1 IGLVV-66 22q11.2 immunoglobulin lambda variable (V)-66 IGLVIV-65 22q11.2 immunoglobulin lambda variable (IV)-65
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  highly
    Lymphoid/Immunethymus   highly
    Nervousnervecranial nerve  highly
    Reproductivemale systemtestis  lowly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • possessing negatively supercoiled DNA relaxing activity
  • catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS