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FLASH GENE
Symbol TOMM34 contributors: - updated : 27-10-2003
HGNC name translocase of outer mitochondrial membrane 34
HGNC id 15746
Location 20q12-q13.11      Physical location : 43.570.771 - 43.589.114
Synonym symbol(s) HTOM34P,TOM34
DNA
TYPE functioning gene
STRUCTURE 18.00 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
large cytosolic C terminal domain,six TPR repeats
HOMOLOGY
Homologene
FAMILY TOM34 family
CATEGORY chaperone/stress , transport carrier
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,outer
basic FUNCTION
  • playing a role in the import of cytosolically synthesized preproteins into mitochondria
  • possessing a weak ATPase activity
  • helping to keep newly synthesized precursors in an unfolded import compatible state
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS mitochondrial transport
    PATHWAY
    metabolism
    signaling
    a component component of the mitochondrial translocase
    INTERACTION
    DNA
    RNA
    small molecule
    protein binding to the mature portion of precursor proteins,HSP90A,VCP,ATP6M,KIAA0665,AMPK and DMAP1 through its TPR repeat
    cell & other binding to cellular components
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS