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FLASH GENE

Symbol

TOMM34

contributors: - updated : 27-10-2003

HGNC name	translocase of outer mitochondrial membrane 34
HGNC id	15746

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	20q12-q13.11      Physical location : 43.570.771 - 43.589.114
Synonym symbol(s)	HTOM34P,TOM34

DNA

TYPE	functioning gene
STRUCTURE	18.00 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

large cytosolic C terminal domain,six TPR repeats

HOMOLOGY

Homologene

FAMILY

TOM34 family

CATEGORY

chaperone/stress , transport carrier

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,outer

basic FUNCTION	playing a role in the import of cytosolically synthesized preproteins into mitochondria
	possessing a weak ATPase activity
	helping to keep newly synthesized precursors in an unfolded import compatible state

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

mitochondrial transport

PATHWAY

metabolism

signaling

a component

component of the mitochondrial translocase

INTERACTION

DNA

RNA

small molecule

protein

binding to the mature portion of precursor proteins,HSP90A,VCP,ATP6M,KIAA0665,AMPK and DMAP1 through its TPR repeat

cell & other

binding to cellular components

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS