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FLASH GENE
Symbol TOMM22 contributors: mct - updated : 05-02-2018
HGNC name translocase of outer mitochondrial membrane 22 homolog (yeast)
HGNC id 18002
Location 22q12-q13      Physical location : 39.077.953 - 39.080.763
Synonym name
  • mitochondrial import receptor
  • Synonym symbol(s) TOM22, 1C9-2, MST065, MSTP065
    DNA
    TYPE functioning gene
    STRUCTURE 2.81 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    PLA2G6 22q13.1-q13.32 phospholipase A2, group VI (cytosolic, calcium-independent) MAFF 22q13.1 v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) C22orf5 22q12 chromosome 22 open reading frame 5 CSNK1E 22q13.1 casein kinase 1, epsilon KCNJ4 22q13.1 potassium inwardly-rectifying channel, subfamily J, member 4 KDELR3 22q13.1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 DDX17 22q13.1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 DMC1 22q13.1 DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast) LOC388900 22 LOC388900 TOMM22 22q12-q13 translocase of outer mitochondrial membrane 22 homolog (yeast) C22orf2 22q12 chromosome 22 open reading frame 2 KIAA0063 22q13.1 chromosome 22 open reading frame 2 GTPBP1 22q13.1 GTP binding protein 1 UNC84B 22q13.1-q13.3 unc-84 homolog B (C. elegans) DNAL4 22q13.1 dynein, axonemal, light polypeptide 4 LOC388901 22 LOC388901 NPTXR 22q13.1 neuronal pentraxin receptor CBX6 22q13.1 chromobox homolog 6 APOBEC3A 22q13.1-q13.2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A APOBEC3B 22q12-q13 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1396 - 142 - 2017 27592226
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
     stomach   highly
    Reproductivefemale systemuteruscervix highly
    Respiratorylung   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal negatively charged region
  • a putative transmembrane region
  • a C terminal intermembrane space region with little negative charge
  • a large cytosolic domain, which has been shown to be sensitive to proteolysis, that appears to function as a receptor in cooperation with TOMM20
  • HOMOLOGY
    interspecies ortholog to murine Tomm22
    ortholog to rattus tom22
    Homologene
    FAMILY TOM22 family
    CATEGORY chaperone/stress , receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    text
  • distributions of clusters of TOMM20 and of TOMM22 follow an inner-cellular gradient from the perinuclear to the peripheral mitochondria
  • basic FUNCTION
  • mitochondrial import receptor having chaperone-like activity
  • import receptor and organizer of the TOM complex involved in protein translocation into mitochondria and has a dual role, as it is a component of the general insertion pore together with the pore-forming protein TOMM40 and, as such, is involved in protein translocation across the mitochondrial outer membrane
  • apparently involved in the same step or sequential steps along the same pathway of targeting signal recognition in import as TOMM20, but may recognize opposite sides of the same presequence in the same step (TOMM20 recognizing the hydrophobic surface and TOMM22 the hydrophilic surface)
  • is a critical regulator of steroidogenesis, and thus, it is essential for mammalian survival
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with several other proteins to import cytosolic preproteins into the mitochondrion
  • core component of the mitochondria outer membrane protein translocation pore
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with TOMM20 and TOMM40
  • mitochondrial receptor for the proapoptotic protein BAX
  • import receptor for proteins lacking conventional mitochondrial presequences
  • interaction with the cytosolic domain of TOMM22 helps BAX to acquire a conformation able to interact with the outer mitochondrial membrane
  • CSNK2A1, CSNK2A2-dependent phosphorylation of TOMM22 is a critical switch for mitophagy and reveal CSNK2A-dependent physiological implications on metabolism, muscle integrity and behavior
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS