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FLASH GENE
Symbol TOM1 contributors: mct - updated : 18-02-2014
HGNC name target of myb1 (chicken)
HGNC id 11982
Location 22q12.3      Physical location : 35.695.267 - 35.743.985
Synonym name target of myb1 (chicken) homolog
Synonym symbol(s) FLJ33404
DNA
TYPE functioning gene
STRUCTURE 48.19 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map cen - D22S277 - HMG2L1 - TOM1 - HMOX1 - MCM5 - qter
Authors Seroussi (99)
Physical map
LOC388895 22 LOC388895 LOC388896 22 hypothetical gene supported by BX537993 COX7BP1 22q13 cytochrome c oxidase subunit VIIb pseudogene 1 HMG2L1 22q13.1 high-mobility group protein 2-like 1 LOC388897 22 LOC388897 TOM1 22q13.1 target of myb1 (chicken) HMOX1 22q13.1 heme oxygenase (decycling) 1 MCM5 22q13.1 MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) RASD2 22q13.1 RASD family, member 2 MB 22q13.1 myoglobin LOC284912 22q13.1 hypothetical gene supported by BC001801 APOL6 22q13.1 apolipoprotein L, 6 MRPS16P3 22q12-q13.1 apolipoprotein L, 6 APOL5 22q13.1 apolipoprotein L, 5 RBM9 22q13.1 RNA binding motif protein 9 RPL41P3 22q13.1 ribosomal protein L41, pseudogene 3 NDUFA9P1 22q12.3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, pseudogene 1 APOL3 22q13.1 apolipoprotein L, 3 APOL4 22q13.1 apolipoprotein L, 4 APOL2 22q13.1 apolipoprotein L, 2 APOL1 22q13.1 apolipoprotein L, 1 MYH9 22q13.1 myosin, heavy polypeptide 9, non-muscle LOC388898 22 LOC388898
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 2396 - 492 - Olsen (2006)
15 - 2399 - 493 - -
14 - 2261 - 447 - -
15 - 2326 - 460 - -
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Endocrinepancreas   lowly
Respiratorylung   lowly
Urinarykidney   lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularstriatumcardiac  
Muscularstriatumskeletal  
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text highly, in placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal domain similar to hepatocyte growth factor regulated tyrosine kinase substrat (HGS), VHS (Vps27p/Hrs/STAM) domain
  • a GAT (GGA and TOM1) domain, both of which are also found in the GGA (Golgi-localizing, gamma-adaptin ear domain homology, ADP-ribosylation factor-binding protein) family of proteins
  • STAM (signal transducing adaptor molecule)
  • a coiled-coil domain in its central port
  • HOMOLOGY
    interspecies ortholog to chicken
    ortholog to murine Tom1
    Homologene
    FAMILY
  • TOM1 family
  • CATEGORY motor/contractile , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • involved in the control of vesicular trafficking to lysosome (suppression of cell growth)
  • involved in the translocation of growth factor receptor complexes to the lysosome for degradation
  • important molecule for membrane recruitment of clathrin, and ZFYVE16 is able to exploit this recruitment at the endosome
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • form a complex with TOLLIP and regulate endosomal trafficking of ubiquitinated proteins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GAT domains interact with ubiquitin and TOLLIP
  • is required for DIAPH2 ubiquitination and degradation during G1 and G2/M phases of the cell cycle, whereas the DIAPH2 protein is stabilized during S phase
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to manic depressive illness (see MAFD15)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS