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FLASH GENE
Symbol TOB2 contributors: mct/npt - updated : 22-05-2010
HGNC name transducer of ERBB2, 2
HGNC id 11980
Location 22q13.2      Physical location : 41.829.491 - 41.843.027
Synonym name protein Tob4
Synonym symbol(s) TROB2, TOBL, TOB4, bK223H9, KIAA1663
DNA
TYPE functioning gene
STRUCTURE 13.54 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map cen - D22S272 - PDGFB - D22S423 - TOB2 - PMM1 - D22S1171 - D22S274 - qter
Authors Gene Map (98)
Physical map
LOC391333 22 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) GPR24 22q13.3 G protein-coupled receptor 24 SLC25A17 22q13.2 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 ST13 22q13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) LOC63929 22q13.31-q13.33 hypothetical protein LOC63929 DNAJB7 22q13.2 DnaJ (Hsp40) homolog, subfamily B, member 7 RBX1 22q13.1 ring-box 1 RPS9P2 22q13.2 ribosomal protein S9 pseudogene 2 LOC391334 22 similar to mutant beta-actin (beta-actin) EP300 22q13.2 E1A binding protein p300 LOC391335 22 similar to KIAA0563 protein L3MBTL2 22q13.31-q13.33 l(3)mbt-like 2 (Drosophila) RANGAP1 22q13.1 Ran GTPase activating protein 1 RoXaN 22q13.2 ubiquitous tetratricopeptide containing protein RoXaN TEF 22q13.1 thyrotrophic embryonic factor TOB2 22q13.2 transducer of ERBB2, 2 PHF5A 22q13.3 PHD finger protein 5A ACO2 22q13.1 aconitase 2, mitochondrial RPC8 22q13.2 RNA polymerase III subunit RPC8 PIPPIN 22q13.2-q13.31 RNA-binding protein pippin PMM1 22q13.2 phosphomannomutase 1 D15Wsu75e 22q13.2 DNA segment, Chr 15, Wayne State University 75, expressed G22P1 22q13.1 thyroid autoantigen 70kDa (Ku antigen) NHP2L1 22q13.2-q13.1 NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae) FLJ23584 22q13.2 hypothetical protein FLJ23584 HMG17L2 22q13.2 high-mobility group (nonhistone chromosomal) protein 17-like 2 MGC40042 22q13.2 hypothetical protein MGC40042 FLJ22349 22q13.2 hypothetical protein FLJ22349 SREBF2 22q13.2 sterol regulatory element binding transcription factor 2 TNFRSF13C 22q13.1-q13.31 tumor necrosis factor receptor superfamily, member 13C C22orf18 22q13.2-q13.31 chromosome 22 open reading frame 18 SEPT3 22q13.2 septin 3 MGC26816 22q13.31 hypothetical protein MGC26816 NAGA 22q13.2 N-acetylgalactosaminidase, alpha- LOC150368 22q13.31 hypothetical protein LOC150368 LOC91689 22q13.31 hypothetical gene supported by AL449243 NDUFA6 22q13.2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa LOC246785 22q13.2 PTD004 pseudogene
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
22 - 4575 - 344 - Hirosawa (2001)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductiveoocyte
cell lineage
cell lines
fluid/secretion sperm
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal half homolog to BTG1
  • a nuclear export signal (NES)
  • a C terminal region containing a sequence rich in proline and glutamine, necessary and sufficient to control its stability (Sasajima 2002), a longer C-terminal region than BTG proteins
  • HOMOLOGY
    Homologene
    FAMILY
  • BTG family
  • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text nuclear localization important for regulation of its antiproliferative activity (Kawamura-Tsuzuku 2004)
    basic FUNCTION
  • may negatively regulate sex steroid hormone action in bone formation (Kawate 2005)
  • play important roles in spermatogenesis, embryonic dorsoventral patterning, osteogenesis, T-cell activation, and learning and memory (Jia 2007)
  • act primarily as transcriptional repressors in several signaling pathways (Jia 2007)
  • implicated in transcription in the nucleus and cytoplasmic mRNA deadenylation and turnover (Winkler 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other degraded by the ubiquitin-proteasome system (Sasajima 2002)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS