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FLASH GENE

Symbol

TOB1

contributors: mct/npt/pgu - updated : 25-05-2014

HGNC name	transducer of ERBB2, 1
HGNC id	11979

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17q21.33      Physical location : 48.939.588 - 48.941.413
Synonym name	protein Tob1
Synonym symbol(s)	TROB, TOB, TROB1, APRO6, APRO6, MGC104792, MGC34446, PIG49

DNA

TYPE	functioning gene
STRUCTURE	1.83 kb     1 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005749 1 - 1830 NP_005740 - 345 - 2007 17785442

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   highly Endocrine adrenal gland       highly Urinary bladder       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol   bone marrow     highly

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic erythroid Lymphoid/Immune lymphocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal half homolog to BTG1
	a nuclear export signal (NES)
	a C terminal region containing a sequence rich in proline and glutamine, necessary and sufficient to control its stability

HOMOLOGY

interspecies

homolog to murine Tob1

intraspecies

homolog to BTG1

Homologene

FAMILY	anti-proliferative TOB1/BTG family
	APRO protein family

CATEGORY

adaptor , regulatory , signaling

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
text	nuclear localization important for regulation of its antiproliferative activity

basic FUNCTION	controling negatively cell growth
	may negatively regulate sex steroid hormone action in bone formation
	play important roles in spermatogenesis, embryonic dorsoventral patterning, osteogenesis, T-cell activation, and learning and memory
	act primarily as transcriptional repressors in several signaling pathways
	implicated in transcription in the nucleus and cytoplasmic mRNA deadenylation and turnover
	involved in the general mechanism of mRNA decay by mediating mRNA deadenylation through interaction with CNOT8 and a general RNA-binding protein, PABPC1
	mediates the recruitment of CNOT8 to the target of CPEB3 and elicits deadenylation and decay of the mRNA

CELLULAR PROCESS	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	ERBB2, SMAD4
	binds directly to CPEB3
	anti-proliferative activity of BTG1, BTG2, BTG3, BTG4, TOB1, TOB2 proteins is mediated through interactions with the CNOT7, CNOT8 deadenylase enzymes

cell & other

REGULATION

Other	degraded by the ubiquitin-proteasome system
	CORO7 is involved in TOB1 degradation
	regulated by multiple ubiquitination machineries

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS