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FLASH GENE
Symbol TOB1 contributors: mct/npt/pgu - updated : 25-05-2010
HGNC name transducer of ERBB2, 1
HGNC id 11979
Location 17q21.33      Physical location : 48.939.588 - 48.941.413
Synonym name protein Tob1
Synonym symbol(s) TROB, TOB, TROB1, APRO6, APRO6, MGC104792, MGC34446, PIG49
DNA
TYPE functioning gene
STRUCTURE 1.83 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
ITGA3 17q22-q23 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) PDK2 17q21.3 pyruvate dehydrogenase kinase, isoenzyme 2 LOC201191 17q21.33 hypothetical protein LOC201191 PPP1R9B 17q21-q22 protein phosphatase 1, regulatory subunit 9B, spinophilin SGCA 17q21 sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) HILS1 17q21.33 spermatid-specific linker histone H1-like protein COL1A1 17q21.31-q22.15 collagen, type I, alpha 1 FLJ33318 17q21.33 hypothetical protein FLJ33318 XYLT2 17q21.3-17q22 xylosyltransferase II MRPL27 17q21.3-q22 mitochondrial ribosomal protein L27 FLJ31364 PRO1855 17q21.33 hypothetical protein PRO1855 FLJ20920 17q21.33 hypothetical protein FLJ20920 MRPS21P9 17q21 mitochondrial ribosomal protein S21 pseudogene 9 CHAD 17q21.33 chondroadherin FLJ11164 17q21.33 hypothetical protein FLJ11164 DKFZp434N1415 17q21.33 Mycbp-associated protein EPN3 17q24.1 epsin 3 FLJ21347 17q21.33 hypothetical protein FLJ21347 LOC253962 17q21.33 hypothetical protein LOC253962 CACNA1G 17q22 calcium channel, voltage-dependent, alpha 1G subunit ABCC3 17q21.3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 MGC15396 17q21.33 hypothetical protein MGC15396 LUC7A 17q21 cisplatin resistance-associated overexpressed protein OA48-18 17q21.33 acid-inducible phosphoprotein FLJ20694 17q21.33 hypothetical protein FLJ20694 LOC390801 17 similar to S100 calcium-binding protein A10; S100 calcium-binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11)); annexin II ligand, calpactin I, light polypeptide WFIKKNRP 17q21.33 WFIKKN-related protein LOC390802 17 similar to ribosomal protein L5; 60S ribosomal protein L5 TOB1 17q21 transducer of ERBB2, 1 SPAG9 17q21.31 sperm associated antigen 9 NME1 17q21.31 non-metastatic cells 1, protein (NM23A) expressed in NME2 17q21.31 non-metastatic cells 2, protein (NM23B) expressed in MBTD1 17q24.1 mbt domain containing 1 CGI-48 17q21.33 CGI-48 protein LOC388401 17 similar to ribosomal protein L7 CA10 17q24 carbonic anhydrase X
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 1830 - 345 - 2007 17785442
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
Endocrineadrenal gland   highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
 bone marrow  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticerythroid
Lymphoid/Immunelymphocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal half homolog to BTG1
  • a nuclear export signal (NES)
  • a C terminal region containing a sequence rich in proline and glutamine, necessary and sufficient to control its stability
    • HOMOLOGY
    interspecies homolog to murine Tob1
    intraspecies homolog to BTG1
    Homologene
    FAMILY
  • anti-proliferative TOB1/BTG family
  • APRO protein family
    • CATEGORY adaptor , regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text nuclear localization important for regulation of its antiproliferative activity
    basic FUNCTION
  • controling negatively cell growth
  • may negatively regulate sex steroid hormone action in bone formation
  • play important roles in spermatogenesis, embryonic dorsoventral patterning, osteogenesis, T-cell activation, and learning and memory
  • act primarily as transcriptional repressors in several signaling pathways
  • implicated in transcription in the nucleus and cytoplasmic mRNA deadenylation and turnover
  • involved in the general mechanism of mRNA decay by mediating mRNA deadenylation through interaction with CNOT8 and a general RNA-binding protein, PABPC1
  • mediates the recruitment of CNOT8 to the target of CPEB3 and elicits deadenylation and decay of the mRNA
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ERBB2, SMAD4
  • binds directly to CPEB3
    • cell & other
    REGULATION
    Other degraded by the ubiquitin-proteasome system
    CORO7 is involved in TOB1 degradation
    regulated by multiple ubiquitination machineries
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS