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FLASH GENE
Symbol TOB1 contributors: mct/npt/pgu - updated : 25-05-2010
HGNC name transducer of ERBB2, 1
HGNC id 11979
Location 17q21.33      Physical location : 48.939.588 - 48.941.413
Synonym name protein Tob1
Synonym symbol(s) TROB, TOB, TROB1, APRO6, APRO6, MGC104792, MGC34446, PIG49
DNA
TYPE functioning gene
STRUCTURE 1.83 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 1830 - 345 - 2007 17785442
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
Endocrineadrenal gland   highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
 bone marrow  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticerythroid
Lymphoid/Immunelymphocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal half homolog to BTG1
  • a nuclear export signal (NES)
  • a C terminal region containing a sequence rich in proline and glutamine, necessary and sufficient to control its stability
  • HOMOLOGY
    interspecies homolog to murine Tob1
    intraspecies homolog to BTG1
    Homologene
    FAMILY
  • anti-proliferative TOB1/BTG family
  • APRO protein family
  • CATEGORY adaptor , regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text nuclear localization important for regulation of its antiproliferative activity
    basic FUNCTION
  • controling negatively cell growth
  • may negatively regulate sex steroid hormone action in bone formation
  • play important roles in spermatogenesis, embryonic dorsoventral patterning, osteogenesis, T-cell activation, and learning and memory
  • act primarily as transcriptional repressors in several signaling pathways
  • implicated in transcription in the nucleus and cytoplasmic mRNA deadenylation and turnover
  • involved in the general mechanism of mRNA decay by mediating mRNA deadenylation through interaction with CNOT8 and a general RNA-binding protein, PABPC1
  • mediates the recruitment of CNOT8 to the target of CPEB3 and elicits deadenylation and decay of the mRNA
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ERBB2, SMAD4
  • binds directly to CPEB3
  • cell & other
    REGULATION
    Other degraded by the ubiquitin-proteasome system
    CORO7 is involved in TOB1 degradation
    regulated by multiple ubiquitination machineries
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS