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FLASH GENE
Symbol TNS3 contributors: mct/ - updated : 28-08-2013
HGNC name tensin 3
HGNC id 21616
Location 7p12.3      Physical location : 47.314.752 - 47.579.199
Synonym name
  • tumor endothelial marker 6
  • tensin-like SH2 domain-containing 1
  • thyroid specific PTB domain protein
  • Synonym symbol(s) TEM6, H_NH0549I23.2, FLJ13732, TENS1
    DNA
    TYPE functioning gene
    STRUCTURE 264.45 kb     31 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    31 - 7639 - 1445 - 2007 17643115
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly Mus musculus
     mouthtongue  highly
    Endocrinethyroid   specific
    Reproductivefemale systemplacenta  highly
    Respiratoryrespiratory tractlarynx  highly
    Urinarykidneytubule  highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialabsorptive excretoryrenal tubular epithelium   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    not specificepithelial cell
    not specificfibroblast
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an Src homology (SH) 2 and a phosphotyrosine-binding (PTB) domain that allows it to interact with the cytoplasmic tail of the beta-integrins
  • a protein phosphatase domain at the N-terminus
  • C-terminal tandem SH2-PTB domain pairing
  • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to murine Tns3
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    basic FUNCTION
  • phosphoprotein phosphatase activity
  • may function as a platform for the disassembly of EGF-related signaling complexes at focal adhesions
  • thought to act as links between the extracellular matrix and the cytoskeleton, and thereby mediate signaling for cell shape and motility
  • implicated as an oncoprotein regulated by SRC and possessing an SH2 domain with a previously undescribed mechanism for the regulation of ligand binding
  • large intracellular proteins believed to link the extracellular matrix to the cytoskeleton via integrins
  • focal adhesion protein that play important roles in signal transduction and cytoskeletal reorganization
  • have the potential to be phosphatases as only their PTPase domains house a cysteine residue that is essential for catalytic activity
  • distinct differences in the cellular expression of TNS1, TENC1, and TNS3, suggesting that they may be able to function independently of each other in the kidney and the small intestine
  • intracellular cytoskeleton-regulating protein, the loss of which is associated with increased cell motility, as has been observed in some human cancer
  • role for Tensin3 in cytoskeletal organisation and cell motility
  • expression of TNS3 and DOCK5 concomitantly increase during osteoclast differentiation
  • DOCK5 and TNS3 cooperate for osteoclast activity, to ensure the correct organization of podosomes
  • CELLULAR PROCESS protein
    PHYSIOLOGICAL PROCESS
    text intracellular signaling cascade
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • regulation of the Rho-GAP activity of DLC1 by TNS3 and TNS4 controls EGF-driven cell migration and transformation
  • regulate DOCK5, a guanine nucleotide exchange factor for the GTPase RAC1, and to modulate podosome-based adhesion structures in osteoclasts
  • cell & other
    REGULATION
    Other EGF induces its phosphorylation and activation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    during tumor angiogenesis
    constitutional fusion      
    with FGFR1 in t(7;8)(p12.3;p11.2) in Kallmann syndrome with cleft lip and cleft palate
    tumoral     --low  
    in thyroid tumor and kidney
    tumoral     --other  
    differential methylation pattern in the TNS3 promoter occurring in renal cell carcinoma, suggesting an epigenetic mechanism for aberrant Tensin downregulation in kidney cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancermetastases 
    anti-metastatic therapies may benefit from restoring or preserving tensin expression in primary tumors
    ANIMAL & CELL MODELS
  • Tns3-null mice exhibit an impaired intestinal epithelial development