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FLASH GENE
Symbol TNS2 contributors: mct - updated : 22-01-2011
HGNC name tensin 2
HGNC id 19737
Location 12q13.13      Physical location : -
Synonym name
  • tensin like C1 domain containing phosphatase (tensin 2)
  • C1 domain-containing phosphatase and tensin-like protein
  • chicken lensin homolog
  • tensin like C1 domain-containing phosphatase
  • Synonym symbol(s) KIAA1075, C1TEN, FLJ16320, DKFZp686D13244, TENC1
    EC.number 3.1.3.-
    DNA
    TYPE functioning gene
    STRUCTURE 17.35 kb     29 Exon(s)
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    29 - 4690 - 1285 - 2002 11792844
    29 splicing 4952 - 1419 - 2002 12470648
    29 splicing 4862 - 1409 - 2002 12470648
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly Homo sapiens
    Digestiveintestinesmall intestine    Mus musculus
     liver   highly Homo sapiens
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveenterocyte Mus musculus
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • actin-binding domain
  • the Src homology 2 (SH2) domain
  • the phosphotyrosine binding (PTB) domain , that predominantly interacts with a novel site on DLC1, not the canonical NPXY motif
  • C1 domain localised preferentially to the nucleus
  • a phosphatase (PTPase) domain that revealed an active site-like pocket receptive towards phosphoinositides
  • HOMOLOGY
    Homologene
    FAMILY
  • tensin family
  • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • plays a role in regulating cell motility
  • intracellular phosphatase that negatively regulates the Akt/PKB signaling cascade, and is similar to its relative PTEN in this respect
  • inhibit cell growth, enhance serum withdrawal-induced apoptosis, and specifically downregulate the PI3K/Akt signalling pathway
  • thought to act as links between the extracellular matrix and the cytoskeleton, and thereby mediate signaling for cell shape and motility
  • large intracellular proteins believed to link the extracellular matrix to the cytoskeleton via integrins
  • negatively regulates the Akt signalling pathway and enhances apoptosis in addition to inhibiting cell migration
  • focal adhesion-localized tensin 2 which negatively regulates DLC1 to permit Rho-mediated actomyosin contraction and remodeling of collagen fibers
  • in addition to regulating cytoskeletal dynamics, influences phosphoinositide-Akt signalling through its PTPase domain
  • have the potential to be phosphatases as only their PTPase domains house a cysteine residue that is essential for catalytic activity
  • may have the unique ability amongst its family members to regulate both cytoskeletal dynamics and survival signalling pathways in parallel
  • important new mediator in THPO/MPL pathway and has a positive affect on cellular growth, at least in part through its effect on the PI3K/Akt signaling
  • distinct differences in the cellular expression of TNS1, TENC1, and TNS3, suggesting that they may be able to function independently of each other in the kidney and the small intestine
  • is an intracellular actin-binding protein that bridges the intracellular portion of transmembrane receptors to the cytoskeleton, thereby regulating signalling for cell shape and motility
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with DLC1 in a PTB domain-dependent manner
  • interaction between DISC1 and TNS2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancermetastases 
    anti-metastatic therapies may benefit from restoring or preserving tensin expression in primary tumors
    ANIMAL & CELL MODELS