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FLASH GENE
Symbol TNRC6C contributors: mct - updated : 21-11-2018
HGNC name trinucleotide repeat containing 6C
HGNC id 29318
Location 17q25.3      Physical location : 76.000.317 - 76.104.916
Synonym symbol(s) FLJ20015, KIAA1582
DNA
TYPE functioning gene
STRUCTURE 149.98 kb     18 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
21 - 9686 - 1690 - 2009 19383768
22 - 9794 - 1726 - 2009 19383768
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   highly
Respiratoryrespiratory tractlarynx  moderately
Visualeye   moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a conserved motif in TNRC6C interacts with the C-terminal domain of polyadenylate binding protein 1 (PABC) and present the crystal structure of the complex
  • C-terminal silencing domain of the GW/TNRC6 proteins interacts with PABP, PAN2/PAN3, and CNOT1/CCR4/CAF1, and C-terminal part of TNRC6C encompassing the RRM RNA-binding motif is a key effector domain mediating protein synthesis repression by TNRC6C
  • HOMOLOGY
    intraspecies paralog to TNRC6A, TNRC6B
    Homologene
    FAMILY GW/TNRC6 family protein
    CATEGORY regulatory , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,nucleus,nucleoplasm
    text
  • localize to the mammalian P bodies
  • basic FUNCTION
  • promoting the binding of methionyl-tRNAi and mRNA
  • TNRC6C, like TNRC6A and TNRC6B, are important for efficient miRNA repression
  • different TNRC6 proteins (TNRC6A, TNRC6B, TNRC6C) have likely distinct functions in different types of RNA granules
  • is likely essential for microvascular maturation during distal airspace sacculation in the developing lung
  • TNRC6A/TNRC6B/TNRC6C are central organizing factors critical to RNA-mediated transcriptional activation
  • central scaffold that link microRNA-associated Argonaute proteins to the cytoplasmic decay machinery for targeted mRNA degradation processes
  • TNRC6A, TNRC6B, TNRC6C are required for transcriptional activation and for the activity of miRNAs but are dispensable for the regulation of splicing, transcriptional silencing, and the action of siRNAs
  • CELLULAR PROCESS nucleotide, transcription, initiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
  • TNRC6A, TNRC6B, and TNRC6C silence the expression of bound mRNAs
  • small molecule
    protein
  • binding to the 40S ribosome
  • binding to the four Ago proteins
  • TNRC6A, TNRC6B, and TNRC6C are recruited to miRNA targets through an interaction between their N-terminal domain and an Argonaute protein
  • GAEC1 regulates the expression of CAPN10 and TNRC6C which predicts survival in esophageal squamous cell carcinoma
  • TRIM65 interacts and colocalizes with trinucleotide repeat containing six (TNRC6A, TNRC6B, TNRC6C) proteins in processing body-like structures
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS