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FLASH GENE
Symbol TNR contributors: mct - updated : 05-02-2015
HGNC name tenascin R (restrictin, janusin)
HGNC id 11953
Location 1q25.1      Physical location : 175.291.934 - 175.712.752
Synonym name
  • janusin
  • restrictin
  • Synonym symbol(s) TNXR, EVI39, KIAA0510
    DNA
    TYPE functioning gene
    SPECIAL FEATURE gene in gene
    text
  • KIAA0510 constitutes the 3'-untranslated region of tenascin-R gene
  • STRUCTURE 420.82 kb     21 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - (D1S242 ,TNR ) - D1S215 - LAMC1 - D1S240 - PDC - D1S412 - D1S504 - CNTN2 - qter
    Authors Williams (97)
    RNA
    TRANSCRIPTS type messenger
    text two alternative forms
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    23 - 5190 - 1358 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain     Homo sapiens
     brainforebraincerebral cortex   Homo sapiensFetal
    Visualeyeretina   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose   
    Nervouscentral    Homo sapiens
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousastrocyte Homo sapiens
    Nervousglia
    Nervousneuron Homo sapiensAdult
    Nervousoligodendrocyte Homo sapiensAdult
    Visualhorizontal association cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a cysteine-rich segment,
  • 4,5 EGF-like repeats
  • 9 fibronectin type III-like repeats
  • a fibrinogen-like sequence
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine loop-tail,putatively
    Homologene
    FAMILY tenascin family
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    text extracellular matrix
    basic FUNCTION
  • inhibitor of CD3-mediated T cell interaction
  • extracellular neural recognition molecule
  • TNC and TNR play antagonistic roles for differentiation and comparably inhibit morphologic maturation
  • is an extracellular matrix glycoprotein that is restricted to the central nervous system, where it acts as a multifunctional and versatile molecule
  • potential role for tenascin-R in corticogenesis
  • TNC and tenascin-R (TNR) play important roles in cell proliferation and migration, fate determination, axonal pathfinding, myelination, and synaptic plasticity
  • role of TNR in brain development and cognition
  • importance of TNR in the regulation of hippocampal neurogenesis, suggesting that TNR acts through distinct direct and indirect mechanisms during development and in the adult
  • TNC and tenascin-R (TNR), regulate differentiation and migration, in addition to neurite outgrowth and survival in numerous types of neurons and mesenchymal progenitor cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text central nervous system development, axon guidance
    PATHWAY
    metabolism
    signaling
    a component
  • aggrecan, link protein and tenascin-R are essential components of the perineuronal net to protect neurons against iron-induced oxidative stress
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with fibronectin-dependent cell attachment and interaction
  • TNC and TNR interfered with the activation of the small GTPase RHOA
  • TNR is likely expressed in a subset of astrocytes and contributes to glutamate homeostasis by regulating astrocytic SLC1A3 expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    in a child with intellectual disability and transient choreoathetosis
    tumoral     --over  
    in pilocytic astrocytomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS