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FLASH GENE
Symbol TNPO1 contributors: mct - updated : 01-02-2010
HGNC name transportin 1
HGNC id 6401
Location 5q13.2      Physical location : 72.112.417 - 72.210.214
Synonym name
  • importin beta 2
  • M9 interacting protein
  • karyopherin (importin) beta 2A
  • Kap beta2A
  • Synonym symbol(s) MIP, TRN, IPO2, MIP1, KPNB2, TRN1
    DNA
    TYPE functioning gene
    STRUCTURE 97.80 kb     25 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    25 - 8546 101.3 890 - -
    25 - 8559 101.3 898 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES acid
    STRUCTURE
    motifs/domains
  • height HEAT repeats
  • one importin N-terminal domain
  • conjugated PhosphoP
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Tnpo1 (99.7pc)
    homolog to rattus Tnpo1 (99.4pc)
    Homologene
    FAMILY
  • karyopherin family
  • importin beta family
  • CATEGORY receptor nuclear , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleolus
    text minimally detected in cytoplasmic processing bodies under normal cell conditions, but largely translocated to stress granules in stressed cells
    basic FUNCTION
  • mediating nuclear import of ribonucleoprotein A1
  • may participate in cellular function of P-bodies (Chang 2009)
  • playing a role in trafficking of ZFP36 between the cytoplasmic granules and whereby modulates the stability of ARE-containing mRNA
  • functions in nuclear protein import as nuclear transport receptor
  • serving as receptor for nuclear localization signals (NLS) in cargo substrates
  • is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin
  • involved in nuclear import of M9-containing proteins
  • mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5
  • plays likely a major role in nuclear localization of FUS
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text nucleocytoplasmic transport, nuclear import of ribosomal proteins
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer composed of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NUP98 involved in the termination of KPNB2 mediated nuclear import
  • binding to HNRPA1, HNRPA2 and mediating nuclear import
  • binding specifically to the GTP-bound form of RAN
  • binding HNRPDL, RPL23A, RPS7, RPL5, SRP19
  • interacting with H2A, H2B, H3 and H4 histones
  • binding to HIV-1 Rev
  • associating with ZFP36 and its AU-rich element-containing mRNA substrates
  • interacting with CCR2, followed by CCR2 receptor internalization
  • HNRNPA1 preferentially binds TNPO1, TNPO2
  • interacting with CD44
  • FUS bind the import-karyopherin, karyopherinbeta2 (TNPO1) in a RAN-sensitive manner
  • cell & other
    REGULATION
    inhibited by NUP98
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS