SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,nucleus,chromatin/chromosome,telomere
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| intracellular,nuclear envelope,pore
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text
| localizes to centrosomes exclusively in G1, coinciding with CENPJ degradation |
basic FUNCTION
| promoting telomere elongation by down-regulation of TERF1, a negative regulator of telomere extension |
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could be auto-regulated by forming dormant protein complexes |
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multifunctional poly(ADP-ribose) polymerase |
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containing epitopes that induce humoral and cellular immune responses in cancer patients |
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TNKS and TNKS2 are critical regulators of canonical Wnt signaling in some cellular contexts |
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TNKS and TNKS2 are core components of the canonical Wnt pathway and their inhibitors should enjoy broad usage as antagonists of Wnt signaling |
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poly(ADP-ribosyl)ates the telomere-binding protein TERF1 |
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tankyrase-1 assembly to large protein complexes masks its telomeric function |
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TNKS multimerization and subsequent larger protein complex formation block its telomeric function |
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component of a regulatory pathway controlling bone homeostasis and inflammatory cytokine production |
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TNKS/TNKS2) catalyze the covalent linkage of ADP-ribose polymer chains onto target proteins, regulating their ubiquitylation, stability, and function |
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play pharmaceutically important roles, at least in telomere homeostasis and Wnt signaling, by covalently ADP-ribosylating target proteins and consequently regulating their functions |
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critical role for TNKS and the canonical Wnt pathway in maintaining lung cancer cells during EGFR inhibition |