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FLASH GENE
Symbol TNIP3 contributors: mct/npt - updated : 20-02-2010
HGNC name TNFAIP3 interacting protein 3
HGNC id 19315
Location 4q27      Physical location : 122.052.565 - 122.137.655
Synonym name
  • putative listeria-induced protein
  • A20-binding inhibitor of NF-B activation 3
  • ABIN-3 beta
  • listeria-induced gene protein
  • Synonym symbol(s) LIND, FLJ21162, ABIN-3
    DNA
    TYPE functioning gene
    STRUCTURE 85.09 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    SEC24D 4q26 SEC24 related gene family, member D (S. cerevisiae) SYNPO2 4q26 synaptopodin 2 MYOZ2 4q26-q27 myozenin 2 MRPL42P1 4q27 myozenin 2 KIAA1350 FABP2 4q28-q31 fatty acid binding protein 2, intestinal LOC201989 4q27 similar to Glycerol kinase, testis specific 1 (ATP:glycerol 3-phosphotransferase) (Glycerokinase) (GK) LOC389221 4 similar to hypothetical protein LOC349114 LOC389222 4 LOC389222 LOC152972 4q27 similar to bA291L22.2 (similar to CDC10 (cell division cycle 10, S. cerevisiae, homolog)) PDE5A 4q26 phosphodiesterase 5A, cGMP-specific LOC391691 4 similar to ARHGAP20 protein MAD2L1 4q27 MAD2 mitotic arrest deficient-like 1 (yeast) LOC344988 4q27 similar to GTP-binding protein SAR1a (COPII-associated small GTPase) PRDM5 4q27 PR domain containing 5 FLJ23191 4q27 hypothetical protein FLJ23191 TNIP3 4q27 TNFAIP3 interacting protein 3 GPR103 4q27 G protein-coupled receptor 103 LOC391692 4 similar to TUBULIN BETA CHAIN ANXA5 4q26-q27 annexin A5 FLJ30834 4q27 hypothetical protein FLJ30834 PMSCL1 4q27 polymyositis/scleroderma autoantigen 1, 75kDa CCNA2 4q27 cyclin A2 BBS7 4q27 Bardet-Biedl syndrome 7 TRPC3 4q25-q27 transient receptor potential cation channel, subfamily C, member 3 KIAA1109 4q28.1 hypothetical protein KIAA1109 Tenr 4q28.1 testis nuclear RNA-binding protein IL2 4q26-q27 interleukin 2 IL21 4q26-q27 interleukin 21 FLJ35630 4q28.1 hypothetical protein FLJ35630 FGF2 4q26 fibroblast growth factor 2 (basic) NUDT6 4q26 nudix (nucleoside diphosphate linked moiety X)-type motif 6 SPATA5 4q27 spermatogenesis associated 5 SPRY1 4q26-q27 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 2429 - 325 - Staege (2001), Verstrepen (2009)
    11 - 2397 - 325 - Staege (2001), Verstrepen (2009)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen    
    Reproductivefemale systemuteruscervix  
    Respiratorylung    
    Visualeye    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three coiled-coil domains
  • an AHD2 region essential for the NF-B inhibiting function of TNIP3
  • an ubiquitin-binding domain that is essential for their NF-kappaB inhibitory and anti-apoptotic activities (Verstrepen 2009)
  • HOMOLOGY
    intraspecies homolog to TNIP2, TNIP3
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • negative feedback regulator of LPS-induced NF-B activation
  • having an important role in the development and progress of septic shock and different autoimmune and chronic inflammatory diseases
  • capable of inhibiting NF-kappaB activation in response to signaling from Toll-like receptor, IL1, and tumor necrosis factor (Weaver 2007)
  • IL10-induced gene product capable of attenuating NF-kappaB in human macrophages (Weaver 2007)
  • lipopolysaccharide (LPS)-inducible protein in monocytes that negatively regulates NF-B activation in response to tumour necrosis factor (TNF) and LPS (Verstrepen 2008)
  • important role in the regulation of immunity and tissue homeostasis (Verstrepen 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • potential role for the TNFAIP3/ABIN complex in the negative feedback regulation of NF-kappaB activation (Verstrepen 2009)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein bind the ubiquitin-editing nuclear factor-kappaB (NF-kappaB) inhibitor protein TNFAIP3 (Verstrepen 2009)
    cell & other
    REGULATION
    induced by induced selectively by IL10 in mononuclear phagocytes coordinately undergoing proinflammatory responses (Weaver 2007)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS