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FLASH GENE
Symbol TNIP2 contributors: mct/npt - updated : 29-03-2008
HGNC name TNFAIP3 interacting protein 2
HGNC id 19118
Location 4p16.3      Physical location : 2.743.386 - 2.758.103
Synonym name
  • LKB1-interacting protein
  • A-20 binding inhibitor of NF-kappa B activation 2
    • Synonym symbol(s) KLIP, FLIP1, ABIN-2, MGC4289, ABIN2
    DNA
    TYPE functioning gene
    STRUCTURE 14.72 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1993 - 429 - Liu (2007)
    - - 1707 - 322 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Lymphoid/Immunespleen   highly
    Reproductivefemale systemuteruscervix highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three structural domains
  • a small globular N- terminal
  • a central alpha-helical coiled coil
  • a large globular C-terminal responsible for the motor activity (it hydrolyzes ATP and binds microtubules)
  • an ubiquitin-binding domain that is essential for their NF-kappaB inhibitory and anti-apoptotic activities (Verstrepen 2009)
  • ABIN homology domain 1 (AHD1) and AHD2
    • HOMOLOGY
    interspecies homolog to murine Trip2
    Homologene
    FAMILY
  • kinesin-like protein family
  • NCD subfamily
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • contributing to the NFKB-inhibitory function of TNFAIP3
  • kinesin that supports microtubule movement in an ATP- dependent manner and has a minus-end directed polarity
  • required for optimal activation of Erk induced by receptors that signal via MAP3K8, including Toll-like receptor 4 and tumor necrosis factor receptor 1 in macrophages, and CD40 in B cells
  • acting to positively regulate the Erk signaling potential by stabilizing MAP3K8
  • important role in the regulation of immunity and tissue homeostasis (Verstrepen 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forms a ternary complex with MAP3K8 and NFKB1 and is essential for MAP3K8 protein stability
  • potential role for the TNFAIP3/ABIN complex in the negative feedback regulation of NF-kappaB activation (Verstrepen 2009)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • zinc finger protein A20 (TNFAIP3)
  • bind the ubiquitin-editing nuclear factor-kappaB (NF-kappaB) inhibitor protein TNFAIP3 (Verstrepen 2009)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS