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FLASH GENE
Symbol TNFSF9 contributors: SGE - updated : 18-05-2009
HGNC name tumor necrosis factor (ligand) superfamily, member 9
HGNC id 11939
Location 19p13.3      Physical location : 6.531.009 - 6.535.939
Synonym name
  • inducible T cell antigen 4-1BB ligand
  • receptor 4-1BB ligand
  • homolog of mouse 4-1BB-L
  • Synonym symbol(s) 4-1BBLG, 4-1BB-L, CD137L, 4-1BBL
    DNA
    TYPE functioning gene
    STRUCTURE 4.93 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1680 26.4 254 - 1993 8405064
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines in various carcinoma cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an extracellular C terminus, a TM1
  • conjugated GlycoP
    mono polymer homomer , trimer
    HOMOLOGY
    Homologene
    FAMILY
  • tumor necrosis factor family
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type II membrane protein
    basic FUNCTION
  • being a ligand for TNFRSF9/4-1BB
  • acting as a costimulatory molecule in T lymphocytes
  • involved in the antigen presentation process and in the generation of cytotoxic T cells
  • reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation
  • is required for the optimal CD8 responses in CD8 T cells
  • is thought to be involved in T cell-tumor cell interaction
  • may have a role in activation-induced cell death (AICD)
  • may play a role in cognate interactions between T-cells and B-cells/macrophages
  • is released following leukocyte activation
  • may be an important mediator for maturation of CD11c(+) myeloid dendritic cells
  • may be indicative of the severity and outcome of rheumatoid arthritis
  • involved in reverse signaling in dendritic cells during the initiation of an adaptive immune response, including dendritic cells maturation, migration and, ultimately, antigen-specific T cell differentiation
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MYC and TNFSF9 are targets of PRDM1 in NK cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    overexpressed in Mantle cell lymphomas
    tumoral        
    altered expression in colorectal cancers, concentration of protein depending on the localization of tumor
    tumoral     --over  
    Increased soluble levels in peripheral blood of patients with multiple sclerosis )
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS