Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TNFSF8 contributors: - updated : 20-12-2005
HGNC name tumor necrosis factor (ligand) superfamily, member 8
HGNC id 11938
Location 9q33      Physical location : 117.665.123 - 117.692.770
Synonym name CD30 ligand on surface of T cells
Synonym symbol(s) CD30LG, CD153, CD30L
DNA
TYPE functioning gene
STRUCTURE 27.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneB cell
cell lineage
cell lines lymphoma cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
an extracellular C terminus
conjugated GlycoP
mono polymer homomer , trimer
HOMOLOGY
interspecies ortholog to murine Tnfsf8
homolog to C.elegans T20D4.2
Homologene
FAMILY tumor necrosis factor (ligand) superfamily
CATEGORY signaling cytokine
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • being a ligand for TNFRSF8/CD30
  • playing an inhibitory role in modulating Ig class switch
  • enhancing cell proliferation of some lymphoma cell lines and CD3-activated T lymphocyte proliferation
  • inducing cell death and reducing cell proliferation of other lymphoma cell lines
  • playing a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS immunity/defense
    text
  • control of cell proliferation
  • induction of apoptosis
  • PATHWAY
    metabolism
    signaling signal transduction
    cell-cell signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein binding to TNFRSF8/CD30
    cell & other
    REGULATION
    induced by CD154 (CD40LG),IL4 and B-cell receptor engagement
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS