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FLASH GENE
Symbol TNFSF4 contributors: mct - updated : 09-02-2008
HGNC name tumor necrosis factor (ligand) superfamily, member 4 (tax-transcriptionally activated glycoprotein 1, 34kDa)
HGNC id 11934
Location 1q25      Physical location : 173.152.870 - 173.176.471
Synonym name
  • OX-40 ligand
  • CD134 ligand
  • glycoprotein 34 kd
  • OX40 antigen ligand
  • tax-transcriptionally activated glycoprotein 1 (34kD)
  • Synonym symbol(s) OX40L, TXGP1, GP34, CD134L, CD252, OX-40L
    DNA
    TYPE anonymous DNA segment
    STRUCTURE 23.00 kb     3 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map cen - DNM3 - PIGC - C1orf9 - FASLG - TNFSF18 - TNFSF4 - PRDX6 - KLHL20 - SERPINC1 - MRPS14 - TNN - TNR - qter
    Authors Wang(05)
    Physical map
    FMO2 1q23-q25 flavin containing monooxygenase 2 FMO1 1q23-q25 flavin containing monooxygenase 1 PRO1257 1q24.1 hypothetical protein PRO1257 FMO4 1q23-q25 flavin containing monooxygenase 4 HCP3 1q23.3 cytochrome c, somatic pseudogene XTP2 1q23.3 HBxAg transactivated protein 2 MYOC 1q24.3-q25.2 myocilin, trabecular meshwork inducible glucocorticoid response LOC391134 1 similar to Chain  , Profilin LOC391135 1 similar to ribosomal protein L4; 60S ribosomal protein L4; homologue of Xenopus ribosomal protein L1 VAMP4 1q24-q25 vesicle-associated membrane protein 4 LOC391136 1 similar to RNA binding motif protein 3 CGI-01 1q24-q25.3 CGI-01 protein LOC391137 1 similar to dJ612B18.1 (similar to 40S ribosomal protein) LOC127099 1q24.1 similar to 60S ACIDIC RIBOSOMAL PROTEIN P1 KIAA0820 1q24 similar to 60S ACIDIC RIBOSOMAL PROTEIN P1 LOC92346 1q24.1 LOC92346 PIGC 1q23-q25 phosphatidylinositol glycan, class C C1orf9 1q24 chromosome 1 open reading frame 9 TNFSF6 1q23.3 tumor necrosis factor (ligand) superfamily, member 6 LOC391138 1 similar to Multisynthetase complex auxiliary component p43 TNFSF18 1q23 tumor necrosis factor (ligand) superfamily, member 18 LOC391139 1 similar to Aspartate aminotransferase, mitochondrial precursor (Transaminase A) (Glutamate oxaloacetate transaminase-2) TNFSF4 1q25 tumor necrosis factor (ligand) superfamily, member 4 (tax-transcriptionally activated glycoprotein 1, 34kDa) LOC343153 1q24.2 similar to ribosomal protein L26 PRDX6 1q24.1 peroxiredoxin 6 MGC43026 1q24.2 hypothetical protein MGC43026 FLJ45235 1q24.2 FLJ45235 protein AB026190 1q24.1-q24.3 Kelch motif containing protein dJ383J4.3 1q24.1 hypothetical gene supported by BC007071 FLJ10514 1q24.2 hypothetical protein FLJ10514 RNU47 1q23.3 RNA, U47 small nuclear MGC2629 1q24.2 hypothetical protein MGC2629 SERPINC1 1q24-q25.1 serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1 KIAA2025 1q24.2 KIAA2025 protein GPR52 1q24 G protein-coupled receptor 52 HHL 1q24 expressed in hematopoietic cells, heart, liver SIP 1q24-q25 expressed in hematopoietic cells, heart, liver MRPS14 1q23-1q25 mitochondrial ribosomal protein S14 LOC388715 1 LOC388715
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 3510 - 183 - Liu (2007)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Lymphoid/Immunelymph node    
    Respiratoryrespiratory tractlarynx   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    an extracellular C terminus
    conjugated GlycoP
    mono polymer homomer , trimer
    HOMOLOGY
    interspecies homolog to murine Tnfsf4
    Homologene
    FAMILY tumor necrosis factor (ligand) superfamily
    CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type II transmembrane glycoprotein (TM1)
    basic FUNCTION
  • playing a role in regulating immune responses
  • involved in T cell antigen-presenting cell (APC) interactions
  • required on activated CD4+ and CD8+ T cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein TNFRSF4 ligand (with its receptor directly mediate adhesion of activated T cells to vascular endothelial cells)
    cell & other
    REGULATION
    induced by on activated CD4+ and CD8+ T cells, and its expression is enhanced by TGF-beta1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    predisposes to SLE either by quantitatively augmenting T cellAPC interaction or by influencing the functional consequences of T cell activation via TNFRSF4
    Susceptibility
  • to atherosclerosis, myocardial infarction
  • to systemic lupus erythematosus (SLE)
  • Variant & Polymorphism SNP
  • SNP increasing the risk of atherosclerosis, myocardial infarction
  • Candidate gene target for atherosclerosis therapy
    Marker
    Therapy target
    ANIMAL & CELL MODELS