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FLASH GENE
Symbol TNFSF18 contributors: mct - updated : 11-05-2016
HGNC name tumor necrosis factor (ligand) superfamily, member 18
HGNC id 11932
Location 1q24.3      Physical location : 173.010.359 - 173.020.103
Synonym name
  • AITR ligand
  • glucocorticoid-induced tumor necrosis receptor (GITR) ligand
  • glucocorticoid-induced TNFR-related protein ligand
  • Synonym symbol(s) AIRTL, GITRL, TL6, MGC138237, hGITRL, AITRL, TNLG2A
    DNA
    TYPE functioning gene
    STRUCTURE 9.74 kb     3 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    LOC388714 1 similar to Putative dimethylaniline monooxygenase [N-oxide forming] 6 (Flavin-containing monooxygenase 6) (FMO 6) (Dimethylaniline oxidase 6) FMO2 1q23-q25 flavin containing monooxygenase 2 FMO1 1q23-q25 flavin containing monooxygenase 1 PRO1257 1q24.1 hypothetical protein PRO1257 FMO4 1q23-q25 flavin containing monooxygenase 4 HCP3 1q23.3 cytochrome c, somatic pseudogene XTP2 1q23.3 HBxAg transactivated protein 2 MYOC 1q24.3-q25.2 myocilin, trabecular meshwork inducible glucocorticoid response LOC391134 1 similar to Chain  , Profilin LOC391135 1 similar to ribosomal protein L4; 60S ribosomal protein L4; homologue of Xenopus ribosomal protein L1 VAMP4 1q24-q25 vesicle-associated membrane protein 4 LOC391136 1 similar to RNA binding motif protein 3 CGI-01 1q24-q25.3 CGI-01 protein LOC391137 1 similar to dJ612B18.1 (similar to 40S ribosomal protein) LOC127099 1q24.1 similar to 60S ACIDIC RIBOSOMAL PROTEIN P1 KIAA0820 1q24 similar to 60S ACIDIC RIBOSOMAL PROTEIN P1 LOC92346 1q24.1 LOC92346 PIGC 1q23-q25 phosphatidylinositol glycan, class C C1orf9 1q24 chromosome 1 open reading frame 9 TNFSF6 1q23.3 tumor necrosis factor (ligand) superfamily, member 6 LOC391138 1 similar to Multisynthetase complex auxiliary component p43 TNFSF18 1q23 tumor necrosis factor (ligand) superfamily, member 18 LOC391139 1 similar to Aspartate aminotransferase, mitochondrial precursor (Transaminase A) (Glutamate oxaloacetate transaminase-2) TNFSF4 1q25 tumor necrosis factor (ligand) superfamily, member 4 (tax-transcriptionally activated glycoprotein 1, 34kDa) LOC343153 1q24.2 similar to ribosomal protein L26 PRDX6 1q24.1 peroxiredoxin 6 MGC43026 1q24.2 hypothetical protein MGC43026 FLJ45235 1q24.2 FLJ45235 protein AB026190 1q24.1-q24.3 Kelch motif containing protein dJ383J4.3 1q24.1 hypothetical gene supported by BC007071 FLJ10514 1q24.2 hypothetical protein FLJ10514 RNU47 1q23.3 RNA, U47 small nuclear MGC2629 1q24.2 hypothetical protein MGC2629 SERPINC1 1q24-q25.1 serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1 KIAA2025 1q24.2 KIAA2025 protein GPR52 1q24 G protein-coupled receptor 52 HHL 1q24 expressed in hematopoietic cells, heart, liver
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 748 - 199 - 2013 23892569
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessels   highly
    Digestiveintestinesmall intestine  highly
    Endocrinepancreas   highly
    Reproductivefemale systemovary  highly
     male systemtestis  highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    Lymphoid/Immunedendritic cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    with an extracellular C terminus
    mono polymer homomer , trimer
    HOMOLOGY
    Homologene
    FAMILY tumor necrosis factor (ligand) superfamily
    CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text type II transmembrane protein (TM1)
    basic FUNCTION
  • maybe involved in interaction between activated T lymphocytes and endothelial cells
  • activating NF-kappa B via TNFR-associated factor 2 (TRAF2) and NF-kappaB inducing kinase (NIK)
  • modulating T lymphocyte survival in peripheral tissues
  • regulator of osteoclast generation and substantiate the major role played by the endothelium in bone physiology
  • may play important role in ocular immunity
  • TNFSF18 utilizes multiple oligomerization states to regulate TNFRSF18-mediated signaling during T cell costimulation
  • TNFRSF18, but also TNFSF18 is capable of transducing signals, and the consequences of TNFRSF18-TNFSF18 interaction may vary among different effector cell types, differ upon signal transduction via the receptor, the ligand, or both, depend on the level of an ongoing immune response
  • could promote Th17 cell differentiation by MAPK14 and STAT3 signaling in autoimmune arthritis
  • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • cell to cell signaling
  • involvement of the TNFRSF18/TNFSF18 pathway in interactions with Epidermal keratinocytes (KCs) and Langerhans cells (LCs) and the migration of dendritic cells (DCs)
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand for receptor TNFRSF18
  • TNFRSF18/TNFSF18 system participates in the development of autoimmune/inflammatory responses and graft vs. host disease and potentiates response to infection and tumors
  • platelet-derived TNFSF18 mediates NK-inhibitory forward signaling via TNFRSF18
  • cell & other
    REGULATION
    Other after stimulation by lipopolysaccharides
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    after stimulation by lipopolysaccharides
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    miscelleaneouspain 
    TNFRSF18-TNFSF18 pathway might represent a novel target for the treatment of neuropathic pain
    ANIMAL & CELL MODELS