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FLASH GENE
Symbol TNFSF14 contributors: mct/npt - updated : 28-05-2010
HGNC name tumor necrosis factor (ligand) superfamily, member 14
HGNC id 11930
Location 19p13.3      Physical location : 6.663.148 - 6.670.599
Synonym name
  • herpesvirus entry mediator A
  • ligand for herpes virus entry mediator
  • tumor necrosis factor receptor-like 2
  • tumor necrosis factor superfamily member LIGHT
  • CD258 antigen
    • Synonym symbol(s) LIGHT, HVEML, TN14, CD258, LTg, TR2
    DNA
    TYPE functioning gene
    STRUCTURE 6.03 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    BGR 19p13.3 bubblegum related protein LOC388497 19 LOC388497 MLLT1 19p13.3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 ASAH3 19p13.3 N-acylsphingosine amidohydrolase (alkaline ceramidase) 3 CLPP 19p13.2 ClpP caseinolytic protease, ATP-dependent, proteolytic subunit homolog (E. coli) SPATA11 19p13.3 spermatogenesis associated 11 PSPN 19p13.3 persephin GTF2F1 19p13.3 general transcription factor IIF, polypeptide 1, 74kDa LOC390877 19 similar to adenylate kinase (EC 2.7.4.3), cytosolic - common carp KHSRP 19p13.3 KH-type splicing regulatory protein (FUSE binding protein 2) MGC34725 19p13.3 hypothetical protein MGC34725 MGC2615 19p13.3 hypothetical protein MGC2615 CRB3 19p13.3 crumbs homolog 3 (Drosophila) FLJ22757 TUBB5 19p13.3 tubulin, beta, 5 TNFSF9 19p13.3 tumor necrosis factor (ligand) superfamily, member 9 TNFSF7 19p13 tumor necrosis factor (ligand) superfamily, member 7 LOC390878 19 similar to 60S ribosomal protein L7 TNFSF14 19p13.3 tumor necrosis factor (ligand) superfamily, member 14 C3 19p13.3 complement component 3 GPR108 19p13.3 G protein-coupled receptor 108 TRIP10 19p13.3 thyroid hormone receptor interactor 10 SH2D3A 19p13.3 SH2 domain containing 3A VAV1 19p13.3 vav 1 oncogene EMR1 19p13.3 egf-like module containing, mucin-like, hormone receptor-like sequence 1 EMR4 19p13.3 egf-like module containing, mucin-like, hormone receptor-like 4 LOC284428 19p13.3 similar to methyl-CpG binding domain protein 3-like 2 MBD3L2 19p13.3 methyl-CpG binding domain protein 3-like 2 LOC388498 19 similar to methyl-CpG binding domain protein 3-like 2 MGC4054 19p13.3 hypothetical protein MGC4054 INSR 19p13.3-p13.2 insulin receptor
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 splicing 1491 - 240 - 1998 9462508
    5 - 1395 - 204 - 1998 9462508
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticplatelet
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an extracellular C terminus
    • conjugated GlycoP
    mono polymer homomer , trimer
    HOMOLOGY
    interspecies homolog to murine Tnfsf14
    Homologene
    FAMILY
  • tumor necrosis factor (ligand) superfamily
    • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    text type II transmembrane protein
    basic FUNCTION
  • inducing apoptosis
  • stimulating the proliferation of T cells and functioning as a costimulatory factor for the activation of lymphoid cells
  • mediated adhesion of platelets to endothelium significantly, occurring both under static and dynamic flow conditions
  • platelet-associated and involved in adhesion of platelets to endothelium while soluble form induces a pro-inflammatory state in vascular endothelial cells
  • may thus be implicated in the pathogenesis of atherosclerosis and acute coronary syndrome, as evidenced by serum levels
  • role for VEGFA and TNFSF14 in macrophage apoptosis during wound healing, an event critical in the resolution of inflammation
  • important mediator in intestinal inflammation
  • might be a critical cytokine involved in the development of autoimmune inflammatory diseases
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forms a membrane-anchored homotrimeric complex that is capable of binding to both lymphotoxin-B receptor (LTbR) and herpes simplex virus entry mediator
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TRAF2 and LTBR (TRAF2, an important
  • effector molecule of TNF signaling, plays a critical, nonredundant role in TNFSF14-LTBR signaling)
    • cell & other
    REGULATION
    induced by VEGFA (increases the expression of tumor necrosis factor superfamily member 14 (TNFSF14/LIGHT) in macrophages)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    on lung inflammatory cells after allergen exposure in asthma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyautoimmune 
    TNFSF14-targeted immunotherapy might be useful in the treatment of autoimmune inflammatory diseases
    immunologyautoimmunedigestive
    in intestinal inflammation may serve as a new target for therapeutic intervention
    allergyasthm 
    may be targeted to prevent asthma-related airway remodeling
    ANIMAL & CELL MODELS