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Symbol TNFSF14 contributors: mct/npt - updated : 07-09-2018
HGNC name tumor necrosis factor (ligand) superfamily, member 14
HGNC id 11930
Location 19p13.3      Physical location : 6.663.148 - 6.670.599
Synonym name
  • herpesvirus entry mediator A
  • ligand for herpes virus entry mediator
  • tumor necrosis factor receptor-like 2
  • tumor necrosis factor superfamily member LIGHT
  • CD258 antigen
  • Synonym symbol(s) LIGHT, HVEML, TN14, CD258, LTg, TR2
    TYPE functioning gene
    STRUCTURE 6.03 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    BGR 19p13.3 bubblegum related protein LOC388497 19 LOC388497 MLLT1 19p13.3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 ASAH3 19p13.3 N-acylsphingosine amidohydrolase (alkaline ceramidase) 3 CLPP 19p13.2 ClpP caseinolytic protease, ATP-dependent, proteolytic subunit homolog (E. coli) SPATA11 19p13.3 spermatogenesis associated 11 PSPN 19p13.3 persephin GTF2F1 19p13.3 general transcription factor IIF, polypeptide 1, 74kDa LOC390877 19 similar to adenylate kinase (EC, cytosolic - common carp KHSRP 19p13.3 KH-type splicing regulatory protein (FUSE binding protein 2) MGC34725 19p13.3 hypothetical protein MGC34725 MGC2615 19p13.3 hypothetical protein MGC2615 CRB3 19p13.3 crumbs homolog 3 (Drosophila) FLJ22757 TUBB5 19p13.3 tubulin, beta, 5 TNFSF9 19p13.3 tumor necrosis factor (ligand) superfamily, member 9 TNFSF7 19p13 tumor necrosis factor (ligand) superfamily, member 7 LOC390878 19 similar to 60S ribosomal protein L7 TNFSF14 19p13.3 tumor necrosis factor (ligand) superfamily, member 14 C3 19p13.3 complement component 3 GPR108 19p13.3 G protein-coupled receptor 108 TRIP10 19p13.3 thyroid hormone receptor interactor 10 SH2D3A 19p13.3 SH2 domain containing 3A VAV1 19p13.3 vav 1 oncogene EMR1 19p13.3 egf-like module containing, mucin-like, hormone receptor-like sequence 1 EMR4 19p13.3 egf-like module containing, mucin-like, hormone receptor-like 4 LOC284428 19p13.3 similar to methyl-CpG binding domain protein 3-like 2 MBD3L2 19p13.3 methyl-CpG binding domain protein 3-like 2 LOC388498 19 similar to methyl-CpG binding domain protein 3-like 2 MGC4054 19p13.3 hypothetical protein MGC4054 INSR 19p13.3-p13.2 insulin receptor
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 splicing 1491 - 240 - 1998 9462508
    5 - 1395 - 204 - 1998 9462508
    Type restricted
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Muscularstriatumskeletal   Homo sapiens
    SystemCellPubmedSpeciesStageRna symbol
    Muscularmyocyte Homo sapiens
    cell lineage
    cell lines
    at STAGE
    physiological period pregnancy
    Text placenta
  • an extracellular C terminus
  • conjugated GlycoP
    mono polymer homomer , trimer
    interspecies homolog to murine Tnfsf14
  • tumor necrosis factor (ligand) superfamily
  • TNF super family protein 14
  • CATEGORY signaling cytokine
        plasma membrane
    text type II transmembrane protein
    basic FUNCTION
  • inducing apoptosis
  • stimulating the proliferation of T cells and functioning as a costimulatory factor for the activation of lymphoid cells
  • mediated adhesion of platelets to endothelium significantly, occurring both under static and dynamic flow conditions
  • platelet-associated and involved in adhesion of platelets to endothelium while soluble form induces a pro-inflammatory state in vascular endothelial cells
  • may thus be implicated in the pathogenesis of atherosclerosis and acute coronary syndrome, as evidenced by serum levels
  • role for VEGFA and TNFSF14 in macrophage apoptosis during wound healing, an event critical in the resolution of inflammation
  • important mediator in intestinal inflammation
  • might be a critical cytokine involved in the development of autoimmune inflammatory diseases
  • regulate bone marrow niche, such as mesenchymal stem cells (MSCs) differentiation
  • may contribute to the pathogenesis of airway fibrosis through enhancement of epithelial–mesenchymal transition (EMT)
  • is a key cytokine in airway inflammation and fibrosis
  • is involved in T-cell homeostasis and erosive bone disease associated with rheumatoid arthritis
  • role of TNFSF14 in multiple myeloma-bone disease development
  • may be an important mediator of skin inflammation and fibrosis in diseases such as scleroderma or atopic dermatitis
  • regulates myogenesis by supporting cell survival and maintaining a sufficient pool of cells for fusion
  • myocyte-derived TNFSF14 is a survival factor necessary for myoblast differentiation and skeletal muscle regeneration
  • promote myeloid differentiation of hematopoietic stem/progenitor cells (HSC/HPCs)
  • exerts its pro-inflammatory and pro-lipogenesis roles through activating nuclear factor-kappa B (NF-&
  • 954;B) signaling pathway
  • inhibits melanogenesis in melanocytes via NFKB1 signaling and could be applied in the treatment of cutaneous pigment disorders
  • can inhibit adipose precursor differentiation into beige adipocytes
  • CELLULAR PROCESS cell life, cell death/apoptosis
    TNFSF14 signaling functions as a mechanism to divert energy in favor of immune activation
    a component
  • forms a membrane-anchored homotrimeric complex that is capable of binding to both lymphotoxin-B receptor (LTbR) and herpes simplex virus entry mediator
    small molecule
  • interacting with TRAF2 and LTBR (TRAF2, an important
  • effector molecule of TNF signaling, plays a critical, nonredundant role in TNFSF14-LTBR signaling)
  • ZFP91 is a key regulator in TNFSF14-induced activation of non-canonical NFKB1 pathway in LTBR signaling
  • TNFSF14 enhanced TGFB1-induced EMT but also induced EMT via the Erk1/2 pathway by itself, without TGFB1 signaling
  • Erk1/2 signaling is essential for TNFSF14-induced EMT
  • is a potent osteoclastogenesis factor that activates the AKT1, NFKB1 and JNK pathways
  • cell & other
    induced by VEGFA (increases the expression of tumor necrosis factor superfamily member 14 (TNFSF14/LIGHT) in macrophages)
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    on lung inflammatory cells after allergen exposure in asthma
    Variant & Polymorphism
    Candidate gene
  • expression of RGS1, TAGAP, TNFSF14, and SH2B3 in peripheral blood mononuclear cells can predict Crohn Disease at least 9 months before the appearance of any clinical and serological signs of the disease
  • Therapy target
    TNFSF14-targeted immunotherapy might be useful in the treatment of autoimmune inflammatory diseases
    in intestinal inflammation may serve as a new target for therapeutic intervention
    may be targeted to prevent asthma-related airway remodeling
    development of TNFSF14 agonists is a potential therapeutics in diet-induced obesity
    potential therapeutic targets for airway remodeling
  • in acute cold stress, Light deficiency in mice accelerated browning in the subcutaneous white adipose tissue (scWAT)
  • bone marrow cells from Tnfsf14 deficient mice appeared to promote diet-induced obesity, insulin resistance and reduced Fgf21 levels in white adipose tissue and liver