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FLASH GENE
Symbol TNFRSF9 contributors: mct/npt - updated : 09-02-2009
HGNC name tumor necrosis factor receptor superfamily, member 9
HGNC id 11924
Location 1p36.23      Physical location : 7.979.907 - 8.000.887
Synonym name
  • cell differentiation antigen CD137 (4-1BB)
  • 4-1BB ligand receptor
  • T cell antigen ILA
  • induced by lymphocyte activation
  • homolog of mouse 4-1BB
  • interleukin-activated receptor, homolog of mouse Ly63
  • Synonym symbol(s) ILA, CD137, 4-1BB, CDw137, MGC2172
    DNA
    TYPE functioning gene
    STRUCTURE 20.98 kb     8 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map pter - D1S2666 - D1S508 - TNFRSF9 - D1S1405 - D1S2407 - cen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1935 - 255 - Zhou (1995)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Connectiveadipose   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    Lymphoid/ImmuneB cell
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four extracytoplasmic cysteine-rich pseudorepeats typical for TNFR superfamily
  • a preligand assembly domain (PLAD) in CRD1 mediating ligand-independent receptor assembly and signaling
  • a small cytoplasmic tail with the DEATH domain
  • mono polymer homomer , trimer
    HOMOLOGY
    Homologene
    FAMILY
  • tumor necrosis factor receptor superfamily
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • activating apoptosis
  • inhibiting lymphocyte proliferation
  • potent T cell costimulatory molecule, having a physiological function that may be the facilitation of monocyte extravasation in inflammatory tissues (Drenkard 2007)
  • can be enhanced on natural killer cells in an Fc-dependent fashion and that expression correlates with phenotypic and functional parameters of activation (Lin 2008)
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TNFRSF9/TNFSF9 interaction plays a central role in sustaining T cell and macrophage activation, i.e. in anti-tumor immunity (Dimberg 2006)
  • TNFRSF18 contributes to TNFRSF9 expression on CD8 T cells upon their entry into the bone marrow (BM) or liver
  • cell & other
    REGULATION
    induced by by proinflammatory cytokines in endothelial cells (Drenkard 2007)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    by hypermethylation in 19p100 of astrocytic tumours and 87p100 of glioma cell lines (Ichimura 2008)
    Susceptibility to rheumatoid arthritis
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS