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FLASH GENE
Symbol TNFRSF6B contributors: mct/npt - updated : 15/11/2008
HGNC name tumor necrosis factor receptor superfamily, member 6b, decoy
HGNC id 11921
Location 20q13.33      Physical location : 62.326.287 - 62.330.033
Synonym name
  • decoy receptor 3
  • decoy receptor for Fas ligand
  • Synonym symbol(s) KIAA1088, M68, NHL, TR6, DCR3, C20orf41, DJ583P15.1.1
    DNA
    TYPE functioning gene
    STRUCTURE 3.75 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - STMN3 - TNFRSF6B - ARFRP1 - qter
    Authors Baļ (00)
    Physical map
    KIAA1510 20q13.33 KIAA1510 protein CHRNA4 20q13.2-q13.3 cholinergic receptor, nicotinic, alpha polypeptide 4 KCNQ2 20q13.3 potassium voltage-gated channel, KQT-like subfamily, member 2 EEF1A2 20q13.3 eukaryotic translation elongation factor 1 alpha 2 LOC149659 20q13.33 hypothetical LOC149659 C20orf149 20q13.33 chromosome 20 open reading frame 149 PTK6 20q13.3 PTK6 protein tyrosine kinase 6 SRMS 20q13.33 src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites MGC5356 20q13.33 hypothetical protein MGC5356 PRIC285 20q13.33 peroxisomal proliferator-activated receptor A interacting complex 285 LOC200213 20q13.33 hypothetical protein LOC200213 GMEB2 20q13.33 glucocorticoid modulatory element binding protein 2 LOC388807 20 LOC388807 STMN3 20q13.3 stathmin-like 3 C20orf41 20q13.3 chromosome 20 open reading frame 41 TNFRSF6B 20q13.3 tumor necrosis factor receptor superfamily, member 6b, decoy ARFRP1 20q13.3 ADP-ribosylation factor related protein 1 KIAA1847 20q13.3 KIAA1847 FLJ20406 20q13.3 hypothetical protein FLJ20406 SLC2A4RG 20q13.33 SLC2A4 regulator FLJ20825 20q13.33 hypothetical protein FLJ20825 C20orf135 20q13.33 chromosome 20 open reading frame 135 TPD52L2 20q13.2-q13.3 tumor protein D52-like 2 LOC388808 20 LOC388808 URKL1 20q13.33 uridine kinase-like 1 KIAA1196 20q13.33 KIAA1196 protein C20orf136 20q13.33 chromosome 20 open reading frame 136 C20orf14 20q13.33 chromosome 20 open reading frame 14
    regionally located located in a gene-rich cluster on chromosome 20, with other potentially tumor-related genes
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 splicing 1124 32.7 300 secreted Bai, Kugathasan (2008)
  • also called variant M68E isoform d
  • containing only the last three exons of variant 1
  • encoding the same isoform than variant M68C
  • - splicing 2290 59.4 545 - Bai
    containing exons 24-34 of variant 1
    - splicing 4946 133.7 1219 - Bai
    lacking the last three exons of variant 1
    7 - 1458 32.7 300 secreted Bai, Kugathasan (2008)
  • also called variant M68C isoform d
  • containing only the last seven exons of variant 1
  • encoding the same isoform than variant M68E
  • - splicing 4945 152.5 1400 - Bai
    containing at least 36 exons
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  moderately
     intestinelarge intestinecolon highly
     stomach   predominantly
    Lymphoid/Immunelymph node   highly
    Respiratoryrespiratory tractlarynx  moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    physiological period fetal
    Text brain, liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • extracytoplasmic cysteine-rich pseudorepeats typical for the TNFR superfamily
  • a preligand assembly domain (PLAD) in CRD1 mediating ligand-independent receptor assembly and signaling
  • a small cytoplasmic domain
  • the DEATH domain, soluble form
  • mono polymer homomer , trimer
    HOMOLOGY
    interspecies ortholog to murine Rtel1
    Homologene
    FAMILY
  • tumor necrosis factor receptor (TNFR) superfamily
  • helicase family
  • RAD3/XPD subfamily
  • stathmin family
  • CATEGORY regulatory , protooncogene , receptor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus
    text type I transmembrane protein (TM1)
    basic FUNCTION
  • required for genome stability and tumor avoidance
  • inhibiting FasL induced apoptosis
  • probable ATP-dependent DNA helicase
  • may be contributing to cell growth and tumor progression
  • involved in both antigen-presenting cell differentiation and lymphocyte function
  • can antagonize homologous recombination at an early stage, after strand invasion, and could promote synthesis-dependent strand annealing
  • CELLULAR PROCESS cell life, differentiation
    cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    text
  • modulation of dendritic cell differentiation
  • maturation as a soluble receptor Fc protein
  • PATHWAY
    metabolism nucleic
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • Fas ligand (TNFRSF6)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    and/or amplified in primary lung,colon and other gastrointestinal tumors
    constitutional     --over  
    in inflamed intestinal epithelia and is secreted by T lymphocytes isolated from individuals with IBD
    tumoral     --other  
    loss of homologous recombination control after deregulation of TNFRSF6B may be a critical event that drives genome instability and cancer
    tumoral     --over  
    in gastrointestinal tract tumors
    Susceptibility
  • to inflammatory bowel disease (IBD), with pediatric-onset
  • to high-grade glioma susceptibility (Wrensch (2009)
  • Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target may prove potentially to be a valuable target for new anticancer therapeutics
    ANIMAL & CELL MODELS