| basic FUNCTION
| tax-transcriptionally activated glycoprotein 1 receptor |
|
involved in T cell-dependent antibody production |
|
female-specific susceptible gene for essential hypertension  |
|
T cell costimulatory molecule, that contributes to T cell expansion, survival, and cytokine production, and potentiate the memory commitment of effector CD8+ T cells |
|
important role of both TNFRSF4 and TNFRSF8 during CD8(+) T-cell activation, and long-term CD8 persistence after contraction is regulated not only by stimulatory receptors but also by the nature of the antigen or how the antigen is presented |
|
required for regulatory T cell-mediated control of colitis |
|
by recruiting T-cell receptor-related intracellular molecules into the TRAF2 complex, provides the T cell with a high level of NFKB activity needed for longevity |
|
novel role for TNFRSF4 in promoting immune tolerance which may have important clinical implications |
|
is necessary for robust CD4(+) T cell memory and confers apparently selective protective immunity against HHV-8 infection in endothelial cells |
|
is critical for optimal clonal expansion and survival of T cells |
|
TNFRSF4, TNFRSF18 play important roles in regulating activities of effector and regulatory T cells (Treg) |
|
TNFRSF4 and IL7 play synergistic, but distinct roles in the homeostatic proliferation of CD4(+) effector memory T (TEM) cells |
|
costimulatory receptor that can potentiate T-cell receptor signalling on the surface of T-lymphocytes |
|
regulates cardiac remodelling via the modulation of CD4+ T-lymphocytes |
|
TNFRSF4 and ICOS act in a cooperative, nonredundant manner to maximize and prolong the T follicular helper (Tfh) response that is generated after acute virus infection |
