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FLASH GENE
Symbol TNFRSF21 contributors: mct - updated : 23-05-2014
HGNC name tumor necrosis factor receptor superfamily, member 21
HGNC id 13469
Location 6p12.3      Physical location : 47.199.268 - 47.277.680
Synonym name
  • death receptor 6
  • TNFR-related death receptor 6
  • Synonym symbol(s) DR6, BM-018, MGC31965, UNQ437/PRO868, CD358
    DNA
    TYPE functioning gene
    STRUCTURE 78.41 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 3662 67.8 655 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   moderately Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousoligodendrocyte Homo sapiens
    cell lineage
    cell lines cervical, lung, colorectal carcinomas and melanomas cell lines
    fluid/secretion
    at STAGE
    Text expressed strongly in immature oligodendrocytes
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N-terminal signal sequence
  • four TNFR like cysteine rich motifs
  • a transmembrane domain
  • a cytoplasmic portion containing a 135AA death domain and a 150 residue tail
  • six extracellular asparagines that are N-glycosylated
  • the Ser/Thr/Pro cluster in the "stalk" domain juxtaposed to the cysteine-rich domains (CRDs) is a major site for the likely mucine-type of O-glycosylation
  • HOMOLOGY
    interspecies ortholog to murine Tnfrsf21
    Homologene
    FAMILY
  • tumor necrosis factor receptor superfamily
  • death receptor subfamily
  • CATEGORY immunity/defense , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text type I transmembrane receptor
    basic FUNCTION
  • involved in inflammation and immune regulation
  • induction of apoptosis and activation of both NF.kappa B and JNK by ectopic expression
  • regulatory role in the activation and function of B cells
  • required for normal cell body death and axonal pruning
  • apparent regulatory function in hematopoietic and neuronal cells
  • participates in the regulation of T-cell activation and/or activity as its genetic disruption results in enhanced CD4+ T-cell expansion
  • negative regulator of oligodendrocyte maturation
  • pivotal role for its signaling in immature oligodendrocyte maturation and myelination
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling signal transduction
    cell death pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TRADD
  • an extracellular fragment of APP, acting via TNFRSF21 and caspase 6, contributes to Alzheimer disease
  • BCL2L1 regulates neuronal outgrowth during development and protects neurites from hypoxic insult, as opposed by TNFRSF21
  • cell & other
    REGULATION
    Other uniquely cleaved from the cell surface of tumor cell lines by MMP14, which is often overexpressed on tumor cells and is associated with malignancy
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    transiently increased in both activated human CD4+ and CD8+ T cells and it is apparently dependent on the activation of NF-KB and NF-AT signaling pathway
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyautoimmunemultiple sclerosis
    new therapeutic avenues for the treatment of demyelination disorders such as multiple sclerosis
    ANIMAL & CELL MODELS
  • Tnfrsf21 knock-out mice
  • Dr6(-/-) mice exhibited enhanced germinal center formation and increased titers of immunoglobulins to T-dependent as well as T-independent type I and II antigens