basic FUNCTION
| involved in inflammation and immune regulation |
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induction of apoptosis and activation of both NF.kappa B and JNK by ectopic expression |
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regulatory role in the activation and function of B cells |
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required for normal cell body death and axonal pruning |
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apparent regulatory function in hematopoietic and neuronal cells |
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participates in the regulation of T-cell activation and/or activity as its genetic disruption results in enhanced CD4+ T-cell expansion |
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negative regulator of oligodendrocyte maturation |
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pivotal role for its signaling in immature oligodendrocyte maturation and myelination |