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FLASH GENE
Symbol TNFRSF19 contributors: mct - updated : 26-08-2010
HGNC name tumor necrosis factor receptor superfamily, member 19
HGNC id 11915
Location 13q12.12      Physical location : 24.144.722 - 24.250.231
Synonym name
  • hypothetical protein TAJ-alpha
  • toxicity and JNK inducer
  • Synonym symbol(s) TROY, TAJ, TRADE, TAJ-ALPHA
    DNA
    TYPE functioning gene
    STRUCTURE 105.51 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure
  • cis-regulatory elements found in promoters of human TNFRSF19 transcripts (Qiu 2010)
  • MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 splicing 1485 - 423 - Kojima (2000), Qiu (2010)
  • also called TRADEbeta
  • 9 exons
  • a 394 aa mature peptide (42.7 kda)
  • TNFRSF19.1
  • 10 splicing 4283 - 417 - Kojima (2000), Qiu (2010)
  • also called TRADEalpha
  • 10 exons
  • having an unique 5' UTR and differing in the 3' end-region which includes a part of the coding sequence compared to variant 1
  • contains a major TRAF2-binding consensus sequence, (P/S/A/T)X(Q/E)E (SLQE at amino acid 413416), which is absent in TNFRSF19.1.
  • a 388 aa mature peptide (42 kda)
  • TNFRSF19.2
  • EXPRESSION
    Rna function in embryo mRNA was exclusively expressed in the epithelium of many tissues, including neuroepithelium;in the developing central nervous system, strongly expressed in the ventricular and subventricular zones (Morikawa 2008)
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   predominantly
    Skin/Tegumentskin appendageshairfollicle highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularexocrinehighly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text brain, skin (epithelium)
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 29 aa signal peptide (3.3 kda)
  • three TNFR-Cys repeats
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Tnfrsf19 (71.1 pc)
    Homologene
    FAMILY
  • tumor necrosis factor receptor superfamily
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text single-pass type I membrane protein
    basic FUNCTION
  • involved in the induction of the caspase-independent apoptosis
  • can mediate activation of JNK and NF-kappa-B
  • acting as a tumor necrosis factor receptor
  • playing an essential role in embryonic development
  • may play some roles in the developing and adult olfactory system (Morikawa 2008)
  • mediating cellular responses to myelin inhibitors
  • essential role in hair follicle development (Pispa 2008)
  • novel function of TNFRSF19 as a factor mediating differentiation signals that determine the mesenchymal (stromal) stem cell differentiating fate into osteoblasts or adipocytes (Qiu 2010)
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling signal transduction
  • JNK cascade
  • EDAR and TNFSFR19 signalling pathways act redundantly to regulate initiation of hair follicle development(Pispa 2008)
  • a component forming a functional receptor complex with NgR and LINGO-1
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associated with TRAF1, TRAF2, TRAF3 and TRAF5 (activation of JNK pathway)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker biomarker for melanoma
    Therapy target
  • also presents a potentially novel cell surface signaling target for inhibitors, cell and/or antibody-based immunotherapies (Spanjaard 2007)
  • ANIMAL & CELL MODELS