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FLASH GENE
Symbol TNFRSF14 contributors: KTN/NPT - updated : NPT
HGNC name tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
HGNC id 11912
Location 1p36.32      Physical location : 2.487.804 - 2.495.265
Synonym name
  • Herpes virus entry mediator
  • CD40-like protein
  • tumor necrosis factor receptor-like gene2
  • Synonym symbol(s) TR2, ATAR, HVEA, HVEM, LIGHTR
    DNA
    TYPE functioning gene
    STRUCTURE 7.46 kb     8 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC388775 1 similar to testis-specific protein NYD-TSP1 MRPL20 1p36.3-36.2 mitochondrial ribosomal protein L20 LOC391207 1 LOC391207 LOC388582 1 LOC388582 WARP 1p36.33 von Willebrand factor A domain-related protein FLJ37183 1p36.33 FLJ37183 protein TOB3 1p36.33 FLJ37183 protein FLJ10709 1p36.33 hypothetical protein FLJ10709 TLR5 1q33.3 toll-like receptor 5 LOC339453 1p36.33 hypothetical LOC339453 HSPC182 1p36.33 HSPC182 protein MMP23A 1p36.3 matrix metalloproteinase 23A SLC35E2 1p36.33 solute carrier family 35, member E2 FLJ13052 1p36.33-p36.21 NAD kinase GNB1 1p36.2 guanine nucleotide binding protein (G protein), beta polypeptide 1 LOC388583 1 similar to hypothetical protein LOC339457 PRKCZ 1p36.33-p36.2 protein kinase C, zeta FLJ31031 1p36.32 hypothetical protein FLJ31031 FLJ14100 1p36.32 hypothetical protein FLJ14100 SKI 1p36.3 v-ski sarcoma viral oncogene homolog (avian) LOC388584 1 LOC388584 FLJ13941 1p36.32 hypothetical protein FLJ13941 RER1 1pter-q24 RER1 homolog (S. cerevisiae) PEX10 1p36.33 peroxisome biogenesis factor 10 KIAA0450 1p36.32 peroxisome biogenesis factor 10 PANK4 1p36.32 pantothenate kinase 4 LOC388585 1 similar to hairy and enhancer of split 5 LOC388586 1 LOC388586 TNFRSF14 1p36.3-p36.22 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) MGC26818 1p36.32 hypothetical protein MGC26818 MMEL2 1p36 membrane metallo-endopeptidase-like 2 LOC390988 1 similar to RIKEN cDNA B230396O12 LOC390989 1 LOC390989 ARPM2  actin-related protein M2 DKFZp761G0122 1p36.32 hypothetical protein DKFZp761G0122 LOC148872 1p36.32 LOC148872 protein PRDM16 1p36.23-p33 PR domain containing 16 ARHGEF16 1p36.32 Rho guanine exchange factor (GEF) 16 EGFL3 1p36.3 EGF-like-domain, multiple 3 LOC388587 1 LOC388587 LOC127262 1p36.32 hypothetical protein LOC127262 WDR8 1p36.3 WD repeat domain 8
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1730 - 283 - -
  • a 38 aa signal peptide of 4.2 kda
  • a 245 aa mature peptide of 26.2 kda
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   moderately
     salivary gland   highly
     stomach   highly
    Endocrineparathyroid   highly
    Lymphoid/Immunespleen    
     thymus   moderately
    Respiratorylung   highly
    Skin/Tegumentskin   predominantly
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three extracytoplasmic cysteine-rich pseudorepeats typical for the TNFR superfamily
  • a preligand assembly domain (PLAD) in CRD1 mediating ligand-independent receptor assembly and signaling
  • a small cytoplasmic domain without catalytic activity
  • conjugated GlycoP
    mono polymer homomer , trimer
    HOMOLOGY
    interspecies homolog to dog TNFRSF14 (58.5 pc)
    homolog to chimpanzee TNFRSF14 (98.2 pc)
    intraspecies homolog to 4-1BB (CD137)
    Homologene
    FAMILY
  • tumor necrosis factor receptor superfamily
  • CATEGORY signaling cytokine , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text
  • single-pass type I transmembrane protein (TM1)
  • external side of plasma membrane
  • basic FUNCTION
  • involved in lymphocyte activation
  • being a receptor for BTLA, TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha
  • playing an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells
  • involved in positive regulation of peptidyl-tyrosine phosphorylation
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
  • cell surface receptor linked signal transduction
  • negative regulation of alpha-beta T cell proliferation
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TRAF2, TRAF3 and TRAF5
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS