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FLASH GENE
Symbol TNFRSF12A contributors: mct/npt - updated : 15/11/2008
HGNC name tumor necrosis factor receptor superfamily, member 12A
HGNC id 18152
Location 16p13.3      Physical location : 3.070.312 - 3.072.381
Synonym name
  • fibroblast growth factor-inducible 14 (Fn14) gene
  • CD266 antigen
  • type I transmembrane protein Fn14
  • Synonym symbol(s) FN14, TWEAKR, A4D5, CD266
    DNA
    TYPE functioning gene
    STRUCTURE 2.02 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    KCTD5 16p13.3 potassium channel tetramerisation domain containing 5 MPN 16p13.3 pancreasin SRRM2 16p13.3 serine/arginine repetitive matrix 2 TCEB2 13q12.1 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) LOC246718 16p12.3 ranscription elongation factor B (SIII), polypeptide 2 (18kD, elongin B) pseudogene EOS 16p13.3 serine protease EOS TESSP1  testis serine protease 1 PRSS21 16p13.3 protease, serine, 21 (testisin) LOC124220 16p13.3 similar to common salivary protein 1 MGC52282 16p13.3 hypothetical protein MGC52282 PRSS22 16p13.3 protease, serine, 22 LOC114984 16p13.3 hypothetical protein BC014089 DKFZp761A132 16p13.3 hypothetical protein DKFZp761A132 FLJ30002 16p13.3 hypothetical protein FLJ30002 KREMEN2 16p13.3 kringle containing transmembrane protein 2 PKMYT1 16p13.3 kringle containing transmembrane protein 2 LOC388205 16 similar to RIKEN cDNA 1520401A03 gene LOC388206 16 LOC388206 CLDN9 16p13.3 claudin 9 CLDN6 16p13.3 claudin 6 TNFRSF12A 16p13.3 tumor necrosis factor receptor superfamily, member 12A HCFC1R1 16p13.3 host cell factor C1 regulator 1 (XPO1 dependant) MGC2655 16p13.3 hypothetical protein MGC2655 LOC146439 16p13.3 similar to CDNA sequence BC038613 MMP25 16p13.3 matrix metalloproteinase 25 MMPL1 16p13.3 matrix metalloproteinase-like 1 NK4 16p13.3 matrix metalloproteinase-like 1 ZNF206 16p13.3 zinc finger protein 206 MGC3771 16p13.3 hypothetical protein MGC3771 ZNF205 16p13.3 zinc finger protein 205 ZNF213 16p13.3 zinc finger protein 213 LOC197350 16p13.3 hypothetical protein LOC197350 OR1F1 16p13.3 olfactory receptor, family 1, subfamily F, member 1 OR1F2 16p13.3 olfactory receptor, family 1, subfamily F, member 2 ZNF200 16p13.3 zinc finger protein 200 MEFV 16p13.3 Mediterranean fever
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1048 - 129 - Dogra (2007)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivesalivary gland   highly
     stomach   highly
    Lymphoid/Immunelymph node    
    Reproductivemale systemprostate   
    Skin/Tegumentskin   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Muscularmyocyte
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, pregnancy
    Text
  • placenta
  • expressed by neural progenitor cells from the early embryonic stages through postnatal development (Hamill 2007)
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one TNFR-Cys repeat
  • HOMOLOGY
    Homologene
    FAMILY
  • tumor necrosis factor receptor superfamily
  • CATEGORY motor/contractile , receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text type 1 membrane protein
    basic FUNCTION
  • involved in angiogenesis and may play a role in cell-matrix interactions
  • may modulate cellular adhesion to matrix
  • proteins
  • required for the expression of myogenic regulatory factors and differentiation of myoblasts into myotubes
  • having a role during myogenic differentiation that could be independent of TWEAK cytokine
  • TWEAK signaling regulates progenitor cell proliferation, differentiation, and survival in multiple organ systems (Hamill 2007)
  • its activation exerts different effects on neural progenitor cells and their progeny depending on the developmental stage of the cells (Hamill 2007)
  • TWEAK/TWEAKR may be important in regulating myocardial structural remodeling and function and may play a role in the pathogenesis of dilated cardiomyopathy (Jain 2009)
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    TNFRSF12A/TNFSF12 pathway is a novel regulator of skeletal muscle precursor cells and illustrate an important mechanism by which inflammatory cytokines influence tissue regeneration and repair
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • receptor fot TWEAK
  • TWEAK/TWEAKR interaction may have proinflammatory effects in retinal pigment epithelial cells (Ebihara 2009)
  • TNSFS12/TNFSFR12A implicated in the pathogenesis of several diseases, including acute ischemic stroke and rheumatoid arthritis (Brown 2010)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS