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FLASH GENE
Symbol TNFRSF12A contributors: mct/npt - updated : 15/11/2008
HGNC name tumor necrosis factor receptor superfamily, member 12A
HGNC id 18152
Location 16p13.3      Physical location : 3.070.312 - 3.072.381
Synonym name
  • fibroblast growth factor-inducible 14 (Fn14) gene
  • CD266 antigen
  • type I transmembrane protein Fn14
    • Synonym symbol(s) FN14, TWEAKR, A4D5, CD266
    DNA
    TYPE functioning gene
    STRUCTURE 2.02 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1048 - 129 - Dogra (2007)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivesalivary gland   highly
     stomach   highly
    Lymphoid/Immunelymph node    
    Reproductivemale systemprostate   
    Skin/Tegumentskin   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Muscularmyocyte
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, pregnancy
    Text
  • placenta
  • expressed by neural progenitor cells from the early embryonic stages through postnatal development (Hamill 2007)
    • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one TNFR-Cys repeat
    • HOMOLOGY
    Homologene
    FAMILY
  • tumor necrosis factor receptor superfamily
    • CATEGORY motor/contractile , receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text type 1 membrane protein
    basic FUNCTION
  • involved in angiogenesis and may play a role in cell-matrix interactions
  • may modulate cellular adhesion to matrix
    • proteins
  • required for the expression of myogenic regulatory factors and differentiation of myoblasts into myotubes
  • having a role during myogenic differentiation that could be independent of TWEAK cytokine
  • TWEAK signaling regulates progenitor cell proliferation, differentiation, and survival in multiple organ systems (Hamill 2007)
  • its activation exerts different effects on neural progenitor cells and their progeny depending on the developmental stage of the cells (Hamill 2007)
  • TWEAK/TWEAKR may be important in regulating myocardial structural remodeling and function and may play a role in the pathogenesis of dilated cardiomyopathy (Jain 2009)
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    TNFRSF12A/TNFSF12 pathway is a novel regulator of skeletal muscle precursor cells and illustrate an important mechanism by which inflammatory cytokines influence tissue regeneration and repair
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • receptor fot TWEAK
  • TWEAK/TWEAKR interaction may have proinflammatory effects in retinal pigment epithelial cells (Ebihara 2009)
  • TNSFS12/TNFSFR12A implicated in the pathogenesis of several diseases, including acute ischemic stroke and rheumatoid arthritis (Brown 2010)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS