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Symbol TNFRSF10D contributors: npt/ - updated : 04-09-2007
HGNC name tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
HGNC id 11907
Location 8p21      Physical location : 22.993.103 - 23.021.540
Synonym name
  • decoy receptor 2
  • TRAIL receptor 4
  • Synonym symbol(s) TRAILR4, DCR2, TRUNDD, CD264
    DNA
    TYPE functioning gene
    STRUCTURE 28.44 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 3561 41.7 386 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text abundantly, in liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two extracellular cysteine rich pseudo-repeats typical for TNFR superfamily
  • a preligand assembly domain (PLAD) in CRD1 mediating ligand-independent receptor assembly and signaling
  • a small cytoplasmic tail
  • a truncated DEATH domain
  • mono polymer homomer , trimer
    HOMOLOGY
    intraspecies homolog to TNF
    Homologene
    FAMILY
  • tumor necrosis factor receptor superfamily
  • CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION
    text type I transmembrane protein (TM1)
    basic FUNCTION
  • apoptosis induced ligand (TRAIL) receptor 4, binding APO2L
  • inducing NFKB and protecting against TRAIL-mediated apoptosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by TP53 inducible
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS