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Symbol TNFRSF10C contributors: npt/ - updated : 04-09-2007
HGNC name tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
HGNC id 11906
Location 8p21      Physical location : 22.960.326 - 22.974.948
Synonym name
  • decoy receptor 1
  • antagonist decoy receptor for TRAIL/Apo-2L
  • TNF related apoptosis-inducing ligand receptor 3
  • lymphocyte inhibitor of TRAIL
  • CD263 antigen
  • Synonym symbol(s) TRAILR3, DCR1, LIT, TRID, CD263, MGC149501, MGC149502
    DNA
    TYPE functioning gene
    STRUCTURE 14.52 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1404 27.4 259 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • an extracellular domain
  • two extracellular cysteine rich pseudo-repeats typical for TNFR superfamily
  • a preligand assembly domain (PLAD) in CRD1 mediating ligand-independent receptor assembly and signaling
  • a small cytoplasmic tail
  • the DEATH domain, but lacking a cytoplasmic domain
  • mono polymer homomer , trimer
    HOMOLOGY
    intraspecies homolog to TNF
    Homologene
    FAMILY
  • tumor necrosis factor receptor superfamily
  • CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION extracellular
    text type I transmembrane protein (TM1)
    basic FUNCTION
  • apoptosis induced ligand (TRAIL) receptor 3, binding APO2L
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS