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FLASH GENE

Symbol

TNFRSF10C

contributors: npt/ - updated : 04-09-2007

HGNC name	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
HGNC id	11906

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	8p21      Physical location : 22.960.326 - 22.974.948
Synonym name	decoy receptor 1
	antagonist decoy receptor for TRAIL/Apo-2L
	TNF related apoptosis-inducing ligand receptor 3
	lymphocyte inhibitor of TRAIL
	CD263 antigen
Synonym symbol(s)	TRAILR3, DCR1, LIT, TRID, CD263, MGC149501, MGC149502

DNA

TYPE	functioning gene
STRUCTURE	14.52 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed TNFRSF10C 5 - 1404 27.4 259 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune lymphocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		Hydrophobic
STRUCTURE

motifs/domains	an extracellular domain
	two extracellular cysteine rich pseudo-repeats typical for TNFR superfamily
	a preligand assembly domain (PLAD) in CRD1 mediating ligand-independent receptor assembly and signaling
	a small cytoplasmic tail
	the DEATH domain, but lacking a cytoplasmic domain

mono polymer

homomer , trimer

HOMOLOGY

intraspecies

homolog to TNF

Homologene

FAMILY

tumor necrosis factor receptor superfamily

CATEGORY

signaling cytokine , receptor

SUBCELLULAR LOCALIZATION	extracellular
text	type I transmembrane protein (TM1)

basic FUNCTION

apoptosis induced ligand (TRAIL) receptor 3, binding APO2L

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS