Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | TNFRSF10B | contributors: mct - updated : 15-10-2020 |
HGNC name | tumor necrosis factor receptor superfamily, member 10b |
HGNC id | 11905 |
|
Location | 8p21.3 Physical location : 22.877.647 - 22.926.700 |
Synonym name | |
| |
| |
| |
| |
| |
Synonym symbol(s) | TRAILR2, DR5, TRICK2, KILLER, KILLER/DR5 , T10B, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9 |
DNA |
TYPE | functioning gene |
STRUCTURE | 48.90 kb 10 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
---|
regulatory sequence | Promoter |
Binding site | |
text structure | two Sp1 binding sites responsible for the basal transcription activity |
MAPPING | cloned | Y | linked | N | status | confirmed |
RNA |
TRANSCRIPTS | type | messenger |
---|
|
EXPRESSION |
Type | ubiquitous |
tissue |
|
cells |
|
cell lineage | highly in tumor cell lineage |
cell lines
fluid/secretion
| |
at STAGE |
physiological period | fetal |
Text | widely in fetal tissues |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
| |
motifs/domains
| |
| |
|
mono polymer | homomer , trimer |
HOMOLOGY |
interspecies | homolog to murine Tnfrsf10b |
Homologene |
FAMILY |
CATEGORY | signaling cytokine , receptor |
SUBCELLULAR LOCALIZATION | plasma membrane |
text | membrane protein type 1 |
basic FUNCTION | |
| |
| |
| |
| |
| |
|
CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling |
a component |
INTERACTION |
DNA |
RNA |
small molecule | metal binding, |
protein | |
| |
| |
| |
|
cell & other |
REGULATION |
induced by | TP53,inducible | |
by luteolin (plays a role in luteolin-induced apoptosis) |
Other | only pro-apoptotic signaling through TNFRSF10A and TNFRSF10B has been found to be regulated by N- and O-glycosylation, respectively |
ASSOCIATED DISORDERS |
corresponding disease(s) |
Other morbid association(s) |
|
Susceptibility | to increased risk of death in non-small cell lung cancer |
Variant & Polymorphism other | polymorphisms and haplotypes associated with increased risk of death in non-small cell lung cancer |
Candidate gene
Marker
| Therapy target
|
|
|
|
ANIMAL & CELL MODELS |