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FLASH GENE
Symbol TNFAIP6 contributors: mct - updated : 11-09-2010
HGNC name tumor necrosis factor, alpha-induced protein 6
HGNC id 11898
Location 2q23.3      Physical location : 152.214.104 - 152.236.559
Synonym name
  • hyaluronate-binding protein
  • TNF-stimulated gene 6 protein
  • TNF alpha-induced protein 6
  • hyaladherin
  • Synonym symbol(s) TSG6, TSG-6
    DNA
    TYPE functioning gene
    STRUCTURE 22.46 kb     6 Exon(s)    single Copie(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site
    text structure AP-1 and NF-IL6 sites, hyaluroman binding site
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC200583 2q23.2-q23.3 similar to Polyadenylate-binding protein 1 (Poly(A)-binding protein 1) (PABP 1) ACVR2 2q22.2-q23.3 activin A receptor, type II ORC4L 2q22-q23 origin recognition complex, subunit 4-like (yeast) MBD5 2q23.2 methyl-CpG binding domain protein 5 DKFZP566F2124 2q23.3 DKFZP566F2124 protein UBBP3 2q22.3 ubiquitin B pseudogene 3 LOC344172 2q23.3 similar to ubiquitin specific protease 8 LOC391451 2 similar to Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2) KIF5C 2q22.3-q32 kinesin family member 5C LOC151276 2q23.3 thioredoxin 1 pseudogene 1 LOC130576 2q23.3 hypothetical protein LOC130576 MGC52057 2q23.3 hypothetical protein MGC52057 CL25022 2q23.3 hypothetical protein CL25022 FLJ32955 2q23.3 hypothetical protein FLJ32955 ARHE 2q23.3 ras homolog gene family, member E LOC339782 2q23.3 hypothetical LOC339782 LOC344332 2q23.3 similar to Fatty acid-binding protein, epidermal (E-FABP) (Psoriasis-associated fatty acid-binding protein homolog) (PA-FABP) LOC389054 2 similar to FLJ45645 protein NMI 22q13.3 N-myc (and STAT) interactor TNFAIP6 2q23.3 tumor necrosis factor, alpha-induced protein 6 DKFZP434D193 2q24.1 DKFZP434D193 protein NEB 2q21.2-q22 nebulin ARL5 2q23.3 ADP-ribosylation factor-like 5 CACNB4 2q22-q23 calcium channel, voltage-dependent, beta 4 subunit STAM2 2q24.1 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 NUDCP1 2q23-q24 nuclear distribution gene C homolog (A. nidulans) pseudogene 1 FNBP3 2q23.3 formin binding protein 3 MGC33864 2q24.1 ADP-ribosylation-like factor 6-interacting protein 6 LOC391452 2 similar to ATP synthase B chain, mitochondrial precursor LOC391453 2 similar to ribosomal protein L23a REPRIMO 2q24.1 candidate mediator of the p53-dependent G2 arrest GALNT13 2q24.1 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13) KCNJ3 2q24.1 potassium inwardly-rectifying channel, subfamily J, member 3 LOC391454 2 similar to ATP synthase alpha chain, mitochondrial precursor NR4A2 2q22-q23 nuclear receptor subfamily 4, group A, member 2 LOC389055 2 LOC389055 GPD2 2q24.1 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1440 - 277 - 2002 11854277
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Hearing/Equilibriumearinnercochlea highly
    Nervousbrain   moderately
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
     chondrocyte
    cell lineage
    cell lines articular joints of osteoarthritis
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal link module that binds hyaluronan
  • a typical cleavage signal peptide
  • C-terminal CUB domain, present in a variety of proteins
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Tnfip6
    homolog to C.elegans y49f6c.3
    Homologene
    FAMILY
  • hyaluronate-binding family
  • CATEGORY adhesion , immunity/defense , receptor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • involved in cell-cell and cell-matrix interactions during inflammation and tumorogenesis
  • playing an essential role in female fertility
  • has a physiological role in bone homeostasis via the regulation of both bone formation and resorption, regulation of bone cell biology with potent effects on two processes that are central to both normal physiology and articular joint disease
  • hyaluronan-binding protein that is involved in ECM remodeling and has anti-inflammatory and chondroprotective functions
  • high affinity ligand that can mediate fibronectin interactions with other matrix components and modulate some interactions of fibronectin with cells
  • coordinated expression of PTX3 and TNFAIP6 may play a role in ECM remodeling at sites of inflammation
  • central to EMT (epithelial-mesenchymal-transition) through effects on hyaluronan macromolecular structure and through CD44-dependent triggering of cell responses
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • hyaluronic acid and aggrecan (adhesion to hyaluronan is involved in cell trafficking in inflammatory processes)
  • binds to osteogenic bone morphogenetic proteins
  • interacting with PTX3 (coordinated expression of PTX3 and TNFAIP6 may play a role in ECM remodeling at sites of inflammation)
  • fibronectin binding to TNFAIP6 is divalent cation-independent and is conserved in cellular fibronectins
  • cell & other
    REGULATION
    induced by TNF-alpha and IL1 and lipopolysaccharide
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in inflammatory lesions and in the ovary during ovulation
    constitutional     --over  
    in the articular joints of osteoarthritis (OA) patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS