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FLASH GENE

Symbol

TNC

contributors: mct - updated : 27-10-2010

HGNC name	tenascin C
HGNC id	5318

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	9q33.3      Physical location : 117.782.805 - 117.880.486
Synonym name	cytotactin, J1 glycoprotein gp150/225
	hexabrachion (tenascin)
	cytotactin
	glioma mesenchymal extracellular matrix
	myotendinous antigen
	neuronectin
	glioma-associated-extracellular matrix antigen
	tenascin-C isoform 14/AD1/16
Synonym symbol(s)	HBR, HTN, HBX, GMEM, TN, JI, MGC167029, GP, 150-225, TN-C, GP 150-225

DNA

TYPE	functioning gene
STRUCTURE	97.68 kb     28 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

Physical map

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002160 28 - 7616 NP_002151 240.8 2201 - - 18305139

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain           spinal cord         Reproductive male system prostate       Respiratory respiratory tract larynx     highly Skin/Tegument skin       highly Urinary bladder       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	15 EGF-like domains
	15 fibronectin type III domains (3th to 5th are heparin-binding site)
	a fibrinogen-like globe domain, a 227–AA(26.9 kDa) globular domain at the C-terminus

conjugated

GlycoP

mono polymer

homomer , hexamer

HOMOLOGY

interspecies

homolog to murine Tnc

Homologene

FAMILY

tenascin family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	extracellular
text	mesenchymal extracellular matrix
	extracellular matrix brain glycoprotein

basic FUNCTION	substrate adhesion molecule of the extra-cellular matrix
	promoting neurite outgrowth of embryonic hippocampal neurons through the alternatively spliced fibronectin type III BD domains via activation of the cell adhesion molecule
	endogenous activator of TLR4-mediated immunity that mediates persistent synovial inflammation and tissue destruction in arthritic joint disease
	playing a potential role in the pathogenesis of rheumatoid arthritis, where its induction upon tissue injury creates a perpetual destructive cycle
	role of tenascin-C as a regulator of the fibrinolytic system
	potential role for this protein in vascular morphogenesis, in matrices of injured and tumor tissues

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	hexamer of the monomers tenascin C or brachion, associated with active epithelial-stromal interactions
	contactin
	a homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends

INTERACTION

DNA

RNA

small molecule

protein	interacting with CTSB in the progression of gliomas
	induced by mutated BMP type II receptors in familial forms of pulmonary arterial hypertension
	interacting with NT5E (a novel and specific receptor for tenascin C and the interaction between these proteins may influence cell adhesion and migration and also lead to decreased generation of local adenosine)
	stromal TNC, predominantly provided by S100A4+ cells, facilitates metastatic colonization

cell & other

REGULATION

induced by	tumor-specific EWSR1-ETS1 fusion gene
		TGFB

repressed by	regulated by FLI1in the development of neural crest cells
		GATA6 (transcriptional repressor of TNC gene expression in fibroblasts

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in breast cancer cells,in astrocytoma and glioma in progression tumoral     --other   expression in pilocytic and diffuse astrocytomas

Susceptibility

to asthma and rhinoconjunctivitis

Variant & Polymorphism other	polymorphisms might play a more independent role for development of upper airway disease such as rhinoconjunctivitis, whereas for asthma, the interplay with other genes, like NPSR1, becomes more prominent

Candidate gene
Marker	aberrant expression of NNAT and TNC was a useful marker for distinguishing malignant peripheral nerve sheath tumor (MPNST) from benign neurofibroma
Therapy target

ANIMAL & CELL MODELS