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Symbol TNC contributors: mct - updated : 06-02-2015
HGNC name tenascin C
HGNC id 5318
Corresponding disease
DFNA56 neurosensory deafness 56
Location 9q33.3      Physical location : 117.782.805 - 117.880.486
Synonym name
  • cytotactin, J1 glycoprotein gp150/225
  • hexabrachion (tenascin)
  • cytotactin
  • glioma mesenchymal extracellular matrix
  • myotendinous antigen
  • neuronectin
  • glioma-associated-extracellular matrix antigen
  • tenascin-C isoform 14/AD1/16
  • Synonym symbol(s) HBR, HTN, HBX, GMEM, TN, JI, MGC167029, GP, 150-225, TN-C, GP 150-225
    TYPE functioning gene
    STRUCTURE 97.68 kb     28 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Physical map
    WDR31 9q33.1 WD repeat domain 31 BSPRY 9q33.1 B-box and SPRY domain containing MGC12904 9q33.1 hypothetical protein MGC12904 ALAD 9q33.3 aminolevulinate, delta-, dehydratase POLE3 9q33 polymerase (DNA directed), epsilon 3 (p17 subunit) C9orf43 9q33.1 chromosome 9 open reading frame 43 RGS3 9q31-q33 regulator of G-protein signalling 3 FLJ31713 9q33.1 hypothetical protein FLJ31713 LOC392385 9 similar to programmed cell death 2 isoform 1; zinc finger protein Rp-8; programmed cell death 2/Rp8 homolog KIAA1952 9q33.1 KIAA1952 protein AMBP 9q32-q33 alpha-1-microglobulin/bikunin precursor KIF12 9q33.1 kinesin family member 12 COL27A1 9q33.1 collagen, type XXVII, alpha 1 ORM1 9q32 orosomucoid 1 ORM2 9q32 orosomucoid 2 AKNA 9q32 AT-hook transcription factor AKNA CIP98 9q33.1 CASK-interacting protein CIP98 ATP6V1G1 9q33.1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G isoform 1 DKFZp547P234 9q33.1 DKFZp547P234 protein LOC389786 9 LOC389786 TNFSF15 9q32 tumor necrosis factor (ligand) superfamily, member 15 LOC392386 9 similar to serine/threonine-protein kinase PRP4K; serine/threonine-protein kinase PRP4 homolog TNFSF8 9q33 tumor necrosis factor (ligand) superfamily, member 8 TNC 9q33.3 tenascin C (hexabrachion) DEC1 9q32 tenascin C (hexabrachion) C9orf27 9q31.3 chromosome 9 open reading frame 27 PAPPA 9q33.1 pregnancy-associated plasma protein A ASTN2 9q33.1 astrotactin 2
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    28 - 7616 240.8 2201 - - 18305139
    Type widely
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumearinnercochlea   Homo sapiensAdult
     spinal cord    
    Respiratoryrespiratory tractlarynx  highly
    Skin/Tegumentskin   highly
    Urinarybladder   highly
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    SystemCellPubmedSpeciesStageRna symbol
    Hearing / Equilibriumcochlea cell Homo sapiens
    cell lineage
    cell lines
    at STAGE
  • 15 EGF-like domains
  • 15 fibronectin type III domains (3th to 5th are heparin-binding site)
  • a fibrinogen-like globe domain, a 227–AA(26.9 kDa) globular domain at the C-terminus
  • conjugated GlycoP
    mono polymer homomer , hexamer
    interspecies homolog to murine Tnc
  • tenascin family
  • CATEGORY structural protein
  • mesenchymal extracellular matrix
  • extracellular matrix brain glycoprotein
  • present in the basilar membrane (BM), and the osseous spiral lamina of the cochlea
  • basic FUNCTION
  • substrate adhesion molecule of the extra-cellular matrix
  • promoting neurite outgrowth of embryonic hippocampal neurons through the alternatively spliced fibronectin type III BD domains via activation of the cell adhesion molecule
  • like TNC, FBLN1 inhibits fibroblast spreading and cell-mediated contraction of a fibrin-FN matrix
  • TNC and TNR play antagonistic roles for differentiation and comparably inhibit morphologic maturation
  • endogenous activator of TLR4-mediated immunity that mediates persistent synovial inflammation and tissue destruction in arthritic joint disease
  • playing a potential role in the pathogenesis of rheumatoid arthritis, where its induction upon tissue injury creates a perpetual destructive cycle
  • role of tenascin-C as a regulator of the fibrinolytic system
  • potential role for this protein in vascular morphogenesis, in matrices of injured and tumor tissues
  • is a critical component of the bone marrow microenvironment that is required for hematopoietic regeneration
  • matricellular protein expressed during embryonic development, as well as in wound healing and cancer invasion in various tissues, and may regulate cell behavior and matrix organization during tissue remodeling
  • TNC and tenascin-R (TNR) play important roles in cell proliferation and migration, fate determination, axonal pathfinding, myelination, and synaptic plasticity
  • in cell interactions during development and, in the adult, in synaptic activity and plasticity, as well as regeneration after injury, TNC is conducive for regeneration and TNR is inhibitory for functional recovery
  • plays an important role in cochlear development
  • unidentified roles for TNC in hemopoiesis: in lineage commitment of thymic T cell progenitors, peripheral T cell migration, and hemopoietic reconstitution
  • TNC and tenascin-R (TNR), regulate differentiation and migration, in addition to neurite outgrowth and survival in numerous types of neurons and mesenchymal progenitor cells
    a component
  • hexamer of the monomers tenascin C or brachion, associated with active epithelial-stromal interactions
  • contactin
  • a homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends
    small molecule
  • interacting with CTSB in the progression of gliomas
  • induced by mutated BMP type II receptors in familial forms of pulmonary arterial hypertension
  • interacting with NT5E (a novel and specific receptor for tenascin C and the interaction between these proteins may influence cell adhesion and migration and also lead to decreased generation of local adenosine)
  • TNC and TNR interfered with the activation of the small GTPase RHOA
  • stromal TNC, predominantly provided by S100A4+ cells, facilitates metastatic colonization
  • downregulates DKK1 promoter activity through the blocking of actin stress fiber formation, activates WNT signaling, and induces WNT target genes in tumor and endothelial cells
  • cell & other
    induced by tumor-specific EWSR1-ETS1 fusion gene
    repressed by regulated by FLI1in the development of neural crest cells
    GATA6 (transcriptional repressor of TNC gene expression in fibroblasts
    corresponding disease(s) DFNA56
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer cells,in astrocytoma and glioma in progression
    tumoral     --other  
    expression in pilocytic and diffuse astrocytomas
    constitutional     --over  
    in scleroderma (SSc), scleroderma spectrum disorder (SSD), and localized scleroderma (LSc)
    Susceptibility to asthma and rhinoconjunctivitis
    Variant & Polymorphism other polymorphisms might play a more independent role for development of upper airway disease such as rhinoconjunctivitis, whereas for asthma, the interplay with other genes, like NPSR1, becomes more prominent
    Candidate gene
  • aberrant expression of NNAT and TNC was a useful marker for distinguishing malignant peripheral nerve sheath tumor (MPNST) from benign neurofibroma
  • realistic and promising biomarker and a target for molecular imaging for the diagnosis of various cardiovascular diseases
  • Therapy target
    potential for TNC as a new therapeutic target in AD
    therapeutic target as a key molecule in the control of the balance of beneficial and undesirable cellular responses during tissue remodeling