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FLASH GENE
Symbol TMSB4Y contributors: - updated : 05-02-2007
HGNC name thymosin, beta 4, Y-linked
HGNC id 11882
Location Yq11.221      Physical location : 15.815.446 - 15.817.897
Synonym symbol(s) TB4Y, TMSL8
DNA
TYPE functioning gene
STRUCTURE 2.00 kb     2 Exon(s)    single Copie(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
regionally located in a AZF deleted region
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary  specific
Nervousbraindiencephalonhypothalamus  
 nerve   moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to the interferon inducible gene 6-26 (4/26)
homolog to TMSB4X
Homologene
FAMILY thymosin beta family
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton
basic FUNCTION
  • acting potentially as an actin sequestering protein, playing a regulatory role in actin polymerization
  • promoting myocardial and endothelial cell migration in the embryonic heart, cardiomyocytes survival and repair
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text
  • cytoskeleton organisation and biogenesis
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with LIMS1 and ILK
  • binding to actin G (monomer)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS