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FLASH GENE
Symbol TMSB10 contributors: mct - updated : 27-05-2015
HGNC name thymosin, beta 10
HGNC id 11879
Location 2p11.2      Physical location : 85.132.762 - 85.133.799
Synonym name
  • migration-inducing gene 12
  • migration-inducing protein 12
  • Synonym symbol(s) TYBO, MIG12, TB10
    DNA
    TYPE functioning gene
    STRUCTURE 1.04 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC388965 2 similar to hepatitis C virus core-binding protein 6; cervical cancer oncogene 3 SUCLG1 2p11.2 succinate-CoA ligase, GDP-forming, alpha subunit FLJ37357 2p11.2 hypothetical protein FLJ37357 LOC200383 2p11.2 similar to Dynein heavy chain at 16F FLJ23529 2p11.2 hypothetical protein FLJ23529 LOC129293 2p11.2 hypothetical protein LOC129293 TMSB10 2p11.2 thymosin, beta 10 KCMF1 2p11.2 potassium channel modulatory factor 1 LOC391388 2 hypothetical gene supported by AJ238095; NM_014463 TCF7L1 2p11.2 transcription factor 7-like 1 (T-cell specific, HMG-box) LOC388966 2 similar to hypothetical protein FLJ20296 TGOLN2 2p11.2 trans-golgi network protein 2 LOC388967 2 LOC388967 LOC388968 2 similar to Phosphatidylethanolamine-binding protein (PEBP) (Prostatic binding protein) (HCNPpp) (Neuropolypeptide h3) (Raf kinase inhibitor protein) (RKIP) FLJ20296 2p11.2 hypothetical protein FLJ20296 FLJ21977 2p11.2 hypothetical protein FLJ21977 CAPG 2cen-q24 capping protein (actin filament), gelsolin-like LOC284948 2p11.2 similar to B-cell linker; B cell linker protein MAT2A 2p11.2 methionine adenosyltransferase II, alpha GGCX 2p12 gamma-glutamyl carboxylase VAMP8 2p11.2-p11.1 vesicle-associated membrane protein 8 (endobrevin) VAMP5 2p11.2 vesicle-associated membrane protein 5 (myobrevin) LOC51255 2p11.2 hypothetical protein LOC51255 FLJ90024 2p11.2 fasting-inducible integral membrane protein TM6P1 LOC388969 2 LOC388969 USP39 2p11.2 ubiquitin specific protease 39 SFTPB 2p12-p11.2 surfactant, pulmonary-associated protein B GNLY 2p12-q11 granulysin HATH6 SIAT9 2p11.2 sialyltransferase 9 (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase; GM3 synthase) POLR1A 2p11.2 polymerase (RNA) 1 polypeptide A, 194kDa
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 482 - 44 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland     Homo sapiensFetal
    Nervousbrain     Homo sapiensFetal
    Urinarykidneytubuleconvoluted tubuledistal tubule  Homo sapiensFetal
     kidneytubuleconvoluted tubuleproximal tubule  Homo sapiensFetal
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveodontoblast Mus musculusFetal
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Tmsb10
    Homologene
    FAMILY thymosin beta family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • actin sequestring protein, playing an important role in the organization of the cytoskeleton
  • TMSB10 and TMSB4X have been implicated in sequestration of monomeric (G-) actin
  • physiological role for TMSB10 in sequestration of G-actin as well as in cancer cell motility
  • regulates actin dynamics as a cytoplasm G-actin sequestering protein
  • participates likely in the formation of the outline of the tooth root
  • stage-specific temporal and spatial expression pattern of TMSB10 in the developing tooth germ is indicative of multiple functions of TMSB10 in the developmental course from initiation to root formation of the tooth germ
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • THRSP can form heterodimers with TMSB10
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    correlates with lymph node metastases of papillary thyroid carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • might be a promising marker and a novel therapeutic target for pancreatic cancer
  • Therapy target
    ANIMAL & CELL MODELS