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FLASH GENE
Symbol TMPRSS4 contributors: mct - updated : 31-01-2017
HGNC name transmembrane protease, serine 4
HGNC id 11878
Location 11q23.3      Physical location : 117.947.726 - 117.990.554
Synonym name
  • transmembrane serine protease 3
  • membrane-type serine protease 2
  • type II membrane serine protease
  • Synonym symbol(s) MT-SP2, TMPRSS3, CAP-H2
    EC.number 3.4.21.-
    DNA
    TYPE functioning gene
    STRUCTURE 42.83 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    KIAA1052 11q23.3 KIAA1052 protein DSCAML1 11q23 Down syndrome cell adhesion molecule like 1 FXYD2 11q23,3 FXYD domain containing ion transport regulator 2 FXYD6 11q23.3 FXYD domain containing ion transport regulator 6 MSP 11q23 mosaic serine protease IL10RA 11q23.3 interleukin 10 receptor, alpha TMPRSS4 11q23.3 transmembrane protease, serine 4 SCN4B 11q23.3 sodium channel, voltage-gated, type IV, beta SCN2B 11q23 sodium channel, voltage-gated, type II, beta AMICA 11q23.3 adhesion molecule AMICA LOC196264 11q23.3 hypothetical protein LOC196264 EVA1 11q24 epithelial V-like antigen 1 CD3E 11q23.3 CD3E antigen, epsilon polypeptide (TiT3 complex) LOC390254 11 similar to carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5; N-acetylglucosamine 6-O-sulfotransferase; I-GLCNAC-6-ST CD3D 11q23.3 CD3D antigen, delta polypeptide (TiT3 complex) CD3G 11q23.3 CD3G antigen, gamma polypeptide (TiT3 complex) UBE4A 11q23.3 ubiquitination factor E4A (UFD2 homolog, yeast) ATP5L 3q27 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g MGC13053 11q23.3 hypothetical protein MGC13053 MLL 11q23 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) FLJ11783 11q23.3 hypothetical protein FLJ11783 LOC143941 11q23.3 similar to CDNA sequence BC021608 FLJ14399 11q23.3 hypothetical protein FLJ14399 FLJ21827 11q23.3 hypothetical protein FLJ21827 ARCN1 11q23.3 archain 1 KIAA0638 11q23.3 archain 1 TREH 11q23.3 trehalase (brush-border membrane glycoprotein)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 3549 48.2 437 - 2003 17968309
    13 - 3534 47.5 432 - -
    - - 3543 47.8 435 - -
    - - 3429 43.6 397 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines pancreatic cancer cells
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal signal-anchor sequence trypsin domain
  • scavenger receptor cysteine rich domain
  • HOMOLOGY
    Homologene
    FAMILY
  • peptidase S1 family
  • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type II transmembrane serine protease
    basic FUNCTION
  • playing a role in metastasis formation and tumor invasion
  • controls the invasive and metastatic potential of cancer cells by facilitating an epithelial-mesenchymal transition
  • promotes invasion, migration and metastasis of tumor cells by facilitating an epithelial-mesenchymal transition (EMT)
  • induces invasion and epithelial-mesenchymal transition through upregulation of ITGA5 and its signaling pathways
  • important role for TMPRSS2 and possibly TMPRSS4 in influenza virus replication and highlight the former protease as a potential therapeutic target
  • maintenance of interphase chromosome compaction and homolog pairing status requires both MORF4L1 and TMPRSS4
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in lung cancer tissues
    tumoral     --over  
    in prostate, colon and gastric cancers, and promote tumor growth, invasion, metastasis and the epithelial-mesenchymal transition (EMT)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • may be a potential therapeutic target for cancer treatment
  • regulation of the EMT by proteases such as TMPRSS4 may provide novel therapeutic targets for a cancer metastasis inhibitor
  • ANIMAL & CELL MODELS