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FLASH GENE

Symbol

TMPRSS4

contributors: mct - updated : 31-01-2017

HGNC name	transmembrane protease, serine 4
HGNC id	11878

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11q23.3      Physical location : 117.947.726 - 117.990.554
Synonym name	transmembrane serine protease 3
	membrane-type serine protease 2
	type II membrane serine protease
Synonym symbol(s)	MT-SP2, TMPRSS3, CAP-H2
EC.number	3.4.21.-

DNA

TYPE	functioning gene
STRUCTURE	42.83 kb     13 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_019894 13 - 3549 NP_063947 48.2 437 - 2003 17968309 NM_001083947 13 - 3534 NP_001077416 47.5 432 - - NM_001173551 - - 3543 NP_001167022 47.8 435 - - NM_001173552 - - 3429 NP_001167023 43.6 397 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Skin/Tegument skin       highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier lining epidermis   highly Homo sapiens

cell lineage
cell lines	pancreatic cancer cells
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal signal-anchor sequence trypsin domain
	scavenger receptor cysteine rich domain

HOMOLOGY

Homologene

FAMILY

peptidase S1 family

CATEGORY

protooncogene

SUBCELLULAR LOCALIZATION	plasma membrane
text	type II transmembrane serine protease

basic FUNCTION	playing a role in metastasis formation and tumor invasion
	controls the invasive and metastatic potential of cancer cells by facilitating an epithelial-mesenchymal transition
	promotes invasion, migration and metastasis of tumor cells by facilitating an epithelial-mesenchymal transition (EMT)
	induces invasion and epithelial-mesenchymal transition through upregulation of ITGA5 and its signaling pathways
	important role for TMPRSS2 and possibly TMPRSS4 in influenza virus replication and highlight the former protease as a potential therapeutic target
	maintenance of interphase chromosome compaction and homolog pairing status requires both MORF4L1 and TMPRSS4

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in lung cancer tissues tumoral     --over   in prostate, colon and gastric cancers, and promote tumor growth, invasion, metastasis and the epithelial-mesenchymal transition (EMT)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	may be a potential therapeutic target for cancer treatment
	regulation of the EMT by proteases such as TMPRSS4 may provide novel therapeutic targets for a cancer metastasis inhibitor

ANIMAL & CELL MODELS