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FLASH GENE
Symbol TMPRSS13 contributors: mct - updated : 02-04-2020
HGNC name transmembrane protease, serine 13
HGNC id 29808
Location 11q23.3      Physical location : 117.771.359 - 117.800.115
Synonym name
  • mosaic serine protease
  • transmembrane protease, serine 11
  • Synonym symbol(s) MSP, MSPL, MSPS, TMPRSS11
    DNA
    TYPE functioning gene
    STRUCTURE 28.81 kb     13 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 3397 - 567 - 2014 25122802
    9 - 2245 - 491 - 2014 25122802
    12 - 3292 - 532 - 2014 25122802
    13 - 2182 - 563 - 2014 25122802
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine   lowly Homo sapiens
    Lymphoid/Immunespleen   highly
     thymus   lowly Homo sapiens
    Reproductivefemale systemovary  highly
     female systembreastmammary gland highly
     female systemplacenta  highly
     male systemprostate  lowly Homo sapiens
    Respiratorylung     Homo sapiens
    Skin/Tegumentskin     Homo sapiens
    Urinarykidney   lowly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningepidermis   Homo sapiens
    Muscularstriatumcardiac lowly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymphocyte
    Skin/Tegumentcornified cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • presence of a transmembrane domain located near the N-terminus
  • a unique and long cytoplasmic tail containing tandem repeat phosphorylation motifs of protein kinases
  • a transmembrane domain, and a trypsin-like serine protease domain at the extracellular C-terminal side
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text
  • dominant form of TMPRSS13 on the cell surface is phosphorylated, whereas intracellular TMPRSS13 is predominantly non-phosphorylated
  • basic FUNCTION
  • play roles in the proteolytic processing of prohormones, precursors of growth factors, and also in the pathogenicity of many viruses and bacteria
  • is a functional protease that is capable of cleaving macromolecular substrates and can be inhibited by serine protease inhibitors of the Kunitz-type
  • TMPRSS13, proteolytically activate membrane fusion activity of the hemagglutinin of highly pathogenic avian influenza viruses and induce their multicycle replication
  • membrane-anchored serine protease that serve as important regulators of multiple developmental and homoeostatic processes 3)
  • contributes to stratum corneum formation and acquisition of the epidermal barrier
  • supports stratum corneum formation and epidermal barrier formation by a mechanism that is independent of both epidermal profilaggrin processing and epidermal tight junction formation
  • membrane-anchored serine protease important for epidermal development and acquisition of epidermal barrier function
  • TMPRSS13 and, to a lesser degree, TMPRSS11E cleave and activate the spike proteins of the Middle East respiratory syndrome and severe acute respiratory syndrome coronaviruses for cell-cell and virus-cell fusion
  • TMPRSS11E and TMPRSS13 activate the S proteins of the SARS- and MERS-CoVs and could contribute to syncytium formation in infected patients
  • TMPRSS11E, TMPRSS13 activate influenza viruses and emerging coronaviruses in cell culture and, because of their expression in human lung tissue, might promote viral spread in the infected host
  • is a glycosylated, active protease and its own proteolytic activity mediates zymogen cleavage
  • exhibits impaired cell-surface expression in the absence of the cognate Kunitz-type serine protease inhibitors, hepatocyte growth factor activator inhibitor SPINT1 or SPINT2
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TMPRSS13 functions as an HGF-converting protease, the activity of which may be regulated by SPINT1
  • cell & other
    REGULATION
    inhibited by strongly inhibited by aprotinin, benzamidine and Bowman-Birk trypsin inhibitor, but poorly inhibited by alpha 1-antitrypsin and leupeptin
    Other phosphorylation of TMPRSS13 is a novel post-translational modification
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinfectious 
    antiviral strategies aiming to prevent viral activation might thus need to encompass inhibitors targeting TMPRSS13 and TMPRSS11E
    ANIMAL & CELL MODELS
    Tmprss13-deficient mice displayed abnormal skin development, leading to a compromised barrier function, as measured by the transepidermal fluid loss rate of newborn mice