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FLASH GENE
Symbol TMPRSS11E contributors: mlc - updated : 05-02-2008
HGNC name transmembrane protease, serine 11E
HGNC id 24265
Location 4q13.2      Physical location : 143.088 - 69.363.321
Synonym name differentially expressed in squamous cell carcinoma gene 1
Synonym symbol(s) DESC1, MGC141972, MGC141974
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 50.00 kb     10 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 2136 - 423 - Kyrieleis (2007)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus    
 mouthtongue   
 pharynx    
Reproductivefemale systemuteruscervix  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a short N-terminal cytoplasmic region
  • a differing set of stem domains
  • a transmembrane segment
  • C-terminal trypsin-like serine proteinase domain, exhibiting a trypsin-like serine proteinase fold with a thrombin-like S1 pocket, a urokinase-type plasminogen activator-type S2 pocket, to accept small residues, and an open hydrophobic S3/S4 cavity to accept large hydrophobic residues
  • HOMOLOGY
    Homologene
    FAMILY hepsin/transmembrane proteinase, serine family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text type II transmembrane protein
    basic FUNCTION
  • functional cell surface serine protease that may have important functions in the epidermis, oral, and reproductive epithelium
  • may be involved in the progression of some type of tumours
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in squamous cell carcinoma of the head and neck region
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target potential therapeutic target in some type of tumours
    ANIMAL & CELL MODELS