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FLASH GENE
Symbol TMPRSS11E contributors: mct - updated : 02-04-2020
HGNC name transmembrane protease, serine 11E
HGNC id 24265
Location 4q13.2      Physical location : 143.088 - 69.363.321
Synonym name differentially expressed in squamous cell carcinoma gene 1
Synonym symbol(s) DESC1, MGC141972, MGC141974, FLJ75331, FLJ94490
EC.number 3.4.21.-
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 50.14 kb     10 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 2122 - 423 - 2014 25122802
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus    
 mouthtongue   
Reproductivefemale systemuteruscervix  
Respiratorylung     Homo sapiens
Skin/Tegumentskin   highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier liningepidermis highly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a short N-terminal cytoplasmic region
  • a differing set of stem domains
  • a transmembrane segment
  • C-terminal trypsin-like serine proteinase domain, exhibiting a trypsin-like serine proteinase fold with a thrombin-like S1 pocket, a urokinase-type plasminogen activator-type S2 pocket, to accept small residues, and an open hydrophobic S3/S4 cavity to accept large hydrophobic residues
  • HOMOLOGY
    Homologene
    FAMILY
  • hepsin/transmembrane proteinase, serine family
  • HAT/HAT-like/DESC subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text type II transmembrane serine protease
    basic FUNCTION
  • functional cell surface serine protease that may have important functions in the epidermis, oral, and reproductive epithelium
  • proteolytic enzyme involved in tissue homeostasis
  • TMPRSS13 and, to a lesser degree, TMPRSS11E cleave and activate the spike proteins of the Middle East respiratory syndrome and severe acute respiratory syndrome coronaviruses for cell-cell and virus-cell fusion
  • TMPRSS11E and TMPRSS13 activate the S proteins of the SARS- and MERS-CoVs and could contribute to syncytium formation in infected patients
  • may be involved in the progression of some type of tumours
  • DESC1 reduced cell viability and sensitized cells to apoptosis, when cells were under apoptotic stimuli
  • may suppress esophageal squamous cell carcinoma (ESCC) development by sensitizing cells to apoptosis under an apoptotic stimulus through downregulating the EGFR/AKT signaling pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • antithrombin III has robust inhibitory properties toward ST14, TMPRSS6, HPN and TMPRSS11E, whereas plasminogen activator inhibitor-1 and alpha(2)-antiplasmin inhibited TMPRSS6, HPN and TMPRSS11E, and to a much lesser extent ST14
  • TMPRSS11E cleaved EGFR and downregulated the EGFR/AKT pathway to favor apoptosis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in squamous cell carcinoma of the head and neck region
    tumoral       loss of function
    during squamous cell carcinoma progression
    constitutional       gain of function
    during normal epithelial differentiation
    tumoral       gain of function
    in Bladder cancer patients when compared with normal subjects
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target potential therapeutic target in some type of tumours
    SystemTypeDisorderPubmed
    immunologyinfectious 
    antiviral strategies aiming to prevent viral activation might thus need to encompass inhibitors targeting TMPRSS13 and TMPRSS11E
    ANIMAL & CELL MODELS