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FLASH GENE
Symbol TMPRSS11B contributors: mct - updated : 08-04-2020
HGNC name transmembrane protease, serine 11B
HGNC id 25398
Location 4q13.2      Physical location : 69.092.371 - 69.111.412
Synonym name human airway trypsin-like protease 5
Synonym symbol(s) DKFZp686L1818, HATL5
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem, component of a cluster
STRUCTURE 19.04 kb     10 Exon(s)
MAPPING cloned   linked   status
RNA
TRANSCRIPTS type
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 2645 - 416 - 2014 24498351
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus     Homo sapiens
 pharynx     Homo sapiens
Respiratoryrespiratory tractlarynx    Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • extracellular (EC) protease domain
  • HOMOLOGY
    Homologene
    FAMILY type II transmembrane serine protease (TTSP) family
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • oncogenic role for TMPRSS11B
  • promotes cell surface expression and solubilization of BSG and this enhances the efficiency of SLC16A4-mediated lactate export, glycolytic flux, and tumor growth
  • acts non-redundantly to enhance lactate secretion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a catalytically active serine protease that is inhibited by the two Kunitz type serine protease inhibitors, hepatocyte growth factor activator inhibitor SPINT1 and SPINT2, as well as by SERPINA1
  • TMPRSS11B promotes solubilization of BSG, an obligate chaperone of SLC16A4, which enhances lactate export and glycolytic metabolism, thereby promoting tumorigenesis
  • TMPRSS11B interacts with BSG and SLC16A4 at the plasma membrane, and TMPRSS11B may influence trafficking of BSG to the plasma membrane
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in human lung squamous cell carcinomas (LSCCs), associated with poor survival
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS